((2R,7aS)-2-Fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol
CAS 2097518-76-6
A "butterfly-shaped" chiral building block for one of oncology's hardest targets: KRAS G12D.
CAS 2097518-76-6 is a small fluorinated bicyclic amino alcohol with an outsized role in modern medicinal chemistry. Its rigid, chiral pyrrolizine framework is used as a key structural unit in KRAS G12D inhibitor programs. The fused rings lock functional groups into a defined 3D arrangement, while the alcohol provides a point for further synthesis. It shows how today's drug discovery often starts from precisely shaped fragments, not just flat aromatic rings.
Published:
2026-09-03
