(1S)-2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol

CAS 223259-63-0

(S)-SPINOL provides a defined chiral framework for constructing more elaborate molecular environments. CAS 223259-63-0 identifies the S enantiomer of a rigid spirocyclic diol. A 2010 study used this starting material to prepare chiral phosphoric acids for asymmetric reactions between indoles and imines. The example demonstrates a documented route from building block to catalytic architecture. It also highlights a necessary distinction: the free diol and the completed phosphoric acid catalyst are different structures. Substituents, substrates, and conditions all contribute to the measured outcome. The S descriptor specifies configuration, not a universal performance guarantee. This compound's story shows how a controlled stereochemical starting point helps researchers investigate the relationship between molecular shape and selective carbon-carbon bond formation in a particular experimental system.