Global Chemical Database

2,3,4,5-Tetrahydro-7,8-dinitro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine

CAS 230615-59-5

2,3,4,5-Tetrahydro-7,8-dinitro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine
Its chemical name is almost a paragraph long. It contains two nitro groups, three fluorines, and a strange bridged ring.
And it appears on the road to a medicine designed to help people stop smoking. CAS 230615-59-5 is a key intermediate in the synthesis of varenicline. What's fascinating is how little the intermediate looks like the final drug.

The two nitro groups are temporary. Chemists reduce them to two neighboring amino groups. Those two -NH2 groups then react with glyoxal and help build an entirely new nitrogen-containing ring. The trifluoroacetyl group is temporary too
Published: 2026-08-16
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