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2'-Amino-5'-hydroxypropiophenone

CAS 35364-15-9

2'-Amino-5'-hydroxypropiophenone
Small synthetic intermediates can sit quietly behind the construction of medicinal chemistry's most elaborate ring systems.
2'-Amino-5'-hydroxypropiophenone (CAS 35364-15-9) has a chemical story that connects molecular identity with practical chemistry. 2'-Amino-5'-hydroxypropiophenone, systematically 1-(2-amino-5-hydroxyphenyl)propan-1-one, is a compact aromatic ketone whose amino, phenolic hydroxyl and ketone functions make it a densely functionalized building block. Specialist synthesis and reference-material sources connect it with intermediates used in irinotecan and other camptothecin-related chemistry. It is not itself an anticancer medicine. Instead, its functional-group arrangement gives chemists entry points for constructing more elaborate fused-ring structures and controlling downstream transformations. It is also encountered as an irinotecan-related impurity or reference material, linking process chemistry with analytical quality control.

Its story also shows why synthesis and analytical control belong together: chemists must create the intended structure, distinguish it from process-related species and verify the form actually being handled.
Published: 2026-09-21
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