Sitagliptin
CAS 486460-32-6
Sitagliptin's story starts with hormone metabolism: understand why GLP-1 disappears so quickly, then design a small molecule to slow that process.
Sitagliptin (CAS 486460-32-6) emerged from Merck's 1999 DPP-4 program: prolong incretin signaling by blocking the enzyme that rapidly inactivates GLP-1.
Published:
2026-09-18
