Global Chemical Database

3-Fluorophenylacetonitrile

CAS 501-00-8

3-Fluorophenylacetonitrile
Can a molecule with only eight carbon atoms become part of the architecture of a modern insomnia medicine?
3-Fluorophenylacetonitrile shows how. It looks simple: a fluorinated benzene ring, a CH2 group, and a nitrile. But the nitrile does something useful. It helps make the neighboring carbon chemically accessible for building new carbon-carbon bonds.

And chemists can use that reactivity to construct something much less obvious: a cyclopropane. This chemistry appears in established synthetic routes to lemborexant, a dual orexin receptor antagonist used to treat insomnia.
Published: 2026-08-16
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