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2-(2-Chloroethoxy)ethanol

CAS 628-89-7

2-(2-Chloroethoxy)ethanol
When does a useful pharmaceutical ingredient become an impurity?
ometimes during the very same manufacturing process. 2-(2-Chloroethoxy)ethanol is a small molecule with two very different ends. One end carries chlorine. The other carries an alcohol. In between is a flexible ether linkage.

That makes it a convenient molecular connector. In established syntheses of quetiapine, the antipsychotic drug, a piperazine nitrogen attacks the carbon bearing chlorine. Chloride leaves. A new C-N bond forms.
Published: 2026-08-18
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