2-Butoxyethanol
[CAS# 111-76-2]

Identification

• Classification: Organic raw materials >> Ether compounds and their derivatives >> Ether, ether alcohol
• Name: 2-Butoxyethanol
• Synonyms: 2-n-Butoxyethanol; Butyl cellosolve; Ethylene glycol monobutyl ether
• Molecular Formula: C₆H₁₄O₂
• Molecular Weight: 118.17
• CAS Registry Number: 111-76-2
• EC Number: 203-905-0
• SMILES: CCCCOCCO

Properties

• Density: 0.9±0.1 g/cm³, Calc.^*, 0.902 g/mL (Expl.)
• Melting point: -75 ºC (Expl.)
• Index of Refraction: 1.418, Calc.^*, 1.419 (Expl.)
• Boiling Point: 167.7±8.0 ºC (760 mmHg), Calc.^*, 169-172.5 ºC (Expl.)
• Flash Point: 60.0±0.0 ºC, Calc.^*, 67 ºC (Expl.)
• Water solubility: miscible (Expl.)

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS06;GHS07 Warning
• Hazard Statements: H331-H302-H315-H319
• Precautionary Statements: P264-P264+P265-P270-P280-P301+P317-P302+P352-P305+P351+P338-P305+P354+P338-P317-P321-P330-P337+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Acute toxicity	Acute Tox.	4	H302
Eye irritation	Eye Irrit.	2	H319
Acute toxicity	Acute Tox.	4	H332
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	3	H331
Acute toxicity	Acute Tox.	3	H311
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Acute toxicity	Acute Tox.	2	H330
Skin sensitization	Skin Sens.	1	H317
Acute toxicity	Acute Tox.	2	H310
Acute toxicity	Acute Tox.	1	H330
Reproductive toxicity	Repr.	2	H361
Germ cell mutagenicity	Muta.	2	H341
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	3	H301
Carcinogenicity	Carc.	2	H351
Specific target organ toxicity - single exposure	STOT SE	1	H370
Flammable liquids	Flam. Liq.	2	H225
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411

• Transport Information: UN 2369

Discovory and Applicatios

2-Butoxyethanol, also known as ethylene glycol monobutyl ether (EGMBE), is an organic solvent with the chemical formula C6H14O2. It is a colorless liquid with a mild odor, and it is commonly used as a solvent in industrial cleaning, coatings, and manufacturing processes. The compound has a broad range of applications due to its excellent solvent properties, particularly in dissolving oils, greases, and resins. Its discovery and extensive use in various industries have made it an essential chemical for many commercial and industrial applications.

2-Butoxyethanol was first synthesized in the 1930s as part of early research into the properties of glycol ethers. The compound is produced by the reaction of butyl alcohol with ethylene oxide, a process that yields a range of glycol ether compounds. As a member of the glycol ether family, 2-butoxyethanol combines the solvent properties of both alcohols and ethers, making it an effective substance for a variety of cleaning and manufacturing tasks. Over time, its role in industrial processes has become more prominent, especially in sectors where high-performance solvents are required.

One of the primary applications of 2-butoxyethanol is in the formulation of cleaning products. Its ability to dissolve oils, greases, and other hydrophobic materials makes it an excellent solvent for degreasing and cleaning operations. It is commonly found in industrial cleaning products such as degreasers, floor cleaners, and graffiti removers. Additionally, it is used in household products like glass cleaners and surface disinfectants. Due to its high solvency power, 2-butoxyethanol can effectively remove stubborn contaminants from surfaces, machinery, and equipment.

In addition to its use as a cleaning agent, 2-butoxyethanol is also widely used as a solvent in the coatings and paint industry. It is included in many formulations for paints, varnishes, and lacquers due to its ability to dissolve a wide range of resins, making it easier to apply and spread the coatings evenly. The compound also helps improve the flow and leveling properties of paints, reducing the occurrence of brush marks and streaks. Furthermore, its low volatility allows for smoother application in environments with varying humidity and temperature levels.

Another key application of 2-butoxyethanol is in the manufacture of inks, adhesives, and hydraulic fluids. It is used in ink formulations for printing because it ensures that the ink dries properly while maintaining good adhesion to surfaces. In adhesives, it functions as a solvent to improve the application and bonding of materials. 2-Butoxyethanol is also used in hydraulic fluid formulations, where it serves as a stabilizing agent and ensures smooth operation in hydraulic systems.

Despite its versatility, 2-butoxyethanol is not without its safety concerns. The compound can pose health risks if not handled properly. Prolonged exposure to 2-butoxyethanol can lead to irritation of the skin, eyes, and respiratory system. Inhalation of the vapors can cause headaches, dizziness, and nausea. The compound is also classified as a possible reproductive toxin, and it may have other long-term health effects if exposure is prolonged or occurs at high concentrations. Therefore, it is important to follow safety guidelines and wear protective equipment when working with this substance.

Due to growing environmental concerns, there have been efforts to replace 2-butoxyethanol in certain applications with safer or more sustainable alternatives. In response to health and environmental risks, manufacturers have developed low-odor and low-toxicity formulations, though 2-butoxyethanol remains a widely used solvent in many industries.

In conclusion, 2-butoxyethanol is an important chemical compound used primarily as a solvent in cleaning products, coatings, inks, and adhesives. Its discovery and subsequent applications have made it indispensable in a variety of industrial and commercial sectors. While its properties make it highly effective in these applications, its potential health and environmental risks necessitate careful handling and ongoing research into safer alternatives.