Dipropylene glycol
[CAS# 25265-71-8]

Identification

• Classification: Organic raw materials >> Alcohols, phenols, phenolic compounds and derivatives >> Acyclic alcohol
• Name: Dipropylene glycol
• Synonyms: Oxydipropanol
• Molecular Formula: C₆H₁₄O₃
• Molecular Weight: 134.17
• CAS Registry Number: 25265-71-8
• EC Number: 246-770-3
• SMILES: CC(CO)OCC(C)O.CC(CO)OC(C)CO.CC(COCC(C)O)O

Properties

• Density: 1.02
• Boiling point: 229-232 ºC
• Refractive index: 1.44-1.442
• Flash point: 138 ºC
• Water solubility: MISCIBLE

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P280-P301+P312-P302+P352-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovory and Applicatios

Dipropylene glycol (DPG) is an organic compound that was first synthesized in the early 20th century as a derivative of propylene glycol. The compound is produced by the reaction of propylene oxide with itself or other glycols to form a colorless, odorless liquid with a range of useful properties.

Dipropylene glycol is a clear, viscous liquid with a slightly sweet odor. It has a boiling point of approximately 230°C (446°F) and a melting point of approximately -60°C (-76°F). The compound is hygroscopic and soluble in water, alcohols, and many organic solvents. DPG is known for its low toxicity and is suitable for a variety of applications, including those in consumer products.

Dipropylene glycol is widely used in the cosmetics and personal care industries for its beneficial properties. DPG is used as a solvent in many cosmetic formulations to enhance the solubility of various active ingredients. It helps to evenly distribute these ingredients in products such as lotions, creams, and perfumes. The compound acts as a humectant, attracting and retaining water in skin care products. This helps to keep the skin hydrated and soft.

In the fragrance industry, DPG is used as a carrier and fixative to dilute and stabilize fragrances, ensuring that the fragrance is evenly distributed and lasts longer. It helps in the uniform release of fragrance in products such as perfumes and air fresheners. The compound prolongs the persistence of fragrance by reducing the evaporation rate of volatile components, thereby prolonging the existence of fragrance.

Dipropylene glycol can be used in various industrial processes. DPG is used in the formulation of industrial lubricants and hydraulic fluids. It acts as a base fluid, provides excellent lubrication properties and reduces mechanical friction. The compound is used in antifreeze formulations to help lower the freezing point and prevent ice formation in cooling systems.

In the food industry, DPG is used as a carrier for flavorings and colorants, ensuring their even distribution and stability in food and beverage products. Various regulatory agencies have deemed the compound safe for use in food.

Dipropylene glycol is also used in the pharmaceutical industry, where it is used as a solvent in various drug formulations, including oral, topical, and injectable drugs. DPG helps solubilize active ingredients and improve the bioavailability of drugs.

Handling dipropylene glycol requires standard safety precautions, using gloves and goggles to prevent direct contact with the compound. While DPG is generally of low toxicity, it is recommended to avoid inhaling vapors. Store DPG in well-sealed containers in a cool, dry place to prevent moisture absorption and degradation.

Dipropylene glycol has a relatively low environmental impact. The compound is biodegradable and breaks down naturally in the environment. However, it should be handled according to local regulations to prevent potential contamination. Proper handling and disposal methods can help mitigate any environmental risks associated with DPG.

References

2024. Promoted Flotation of Lead and Silver Oxidized Minerals Using a Synergetic Combination of Collectors. Journal of Sustainable Metallurgy.
DOI: 10.1007/s40831-024-00867-6

2011. Synthesis, physicochemical characteristics and properties of oligomeric surfactants based on pentaerythritol and propylene oxide. Russian Journal of Applied Chemistry.
DOI: 10.1134/s1070427211070111

Substances from Second NORMAN Collaborative Dust Trial.
DOI: 10.5281/zenodo.13835254