Cocamidopropyl betaine
[CAS# 86438-79-1]

Identification

• Classification: Organic raw materials >> Amino compound >> Amide compound
• Name: Cocamidopropyl betaine
• Synonyms: N-Cocamidopropyl-N,N-dimethylglycine inner salt; N-(3-Cocoamidopropyl)-betaine
• Molecular Formula: C₁₉H₃₈N₂O₃
• Molecular Weight: 342.52
• CAS Registry Number: 86438-79-1 (61789-40-0)
• EC Number: 617-861-9
• SMILES: CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(=O)[O-]

Safety Data

• Hazard Symbols: GHS05 Danger
• Hazard Statements: H318
• Precautionary Statements: P280-P305+P351+P338+P310

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318

Discovory and Applicatios

Cocamidopropyl betaine is an amphoteric surfactant derived from coconut oil and dimethylaminopropylamine. It was first introduced in the 1980s as a secondary surfactant in personal care formulations. The compound is created by reacting coconut oil with a mixture of chemicals, which includes the amino alcohol dimethylaminopropylamine, resulting in the formation of a betaine structure. This unique molecular composition allows cocamidopropyl betaine to function effectively in a wide range of applications.

One of the primary uses of cocamidopropyl betaine is in personal care products, particularly in shampoos, body washes, and facial cleansers. It is valued for its ability to act as a mild cleanser and foaming agent while maintaining the skin's natural moisture balance. Due to its amphoteric nature, cocamidopropyl betaine can work in both acidic and basic conditions, making it versatile and effective across various product formulations. It also enhances the foam quality in cleansing products, which is a desirable characteristic in consumer goods.

Cocamidopropyl betaine is often used in combination with other surfactants, such as sodium lauryl sulfate, to create a synergistic effect that balances cleaning power with gentleness. In formulations, it helps reduce the potential irritation that may be caused by harsher surfactants, making it a popular choice for sensitive skin products. This gentle nature is also why cocamidopropyl betaine is commonly found in products designed for babies, such as baby shampoos and wipes.

In addition to its role in personal care products, cocamidopropyl betaine is used in household cleaning products, including dishwashing liquids and surface cleaners. Its surfactant properties help break down oils and grease, allowing for effective cleaning without harsh chemicals. Its ability to function well in various pH environments makes it suitable for a wide array of cleaning tasks.

Cocamidopropyl betaine has also found applications in industrial formulations, where it serves as a foam stabilizer in applications such as oil recovery, agriculture, and textile processing. Its ability to create stable foam under various conditions makes it a useful additive in these processes.

The safety of cocamidopropyl betaine has been extensively studied, and it is generally regarded as safe for use in personal care and cleaning products. However, as with many ingredients derived from natural sources, some individuals may experience sensitivities or allergic reactions to the compound. Despite this, its widespread use in cosmetic formulations attests to its overall safety and efficacy when used as directed.

The discovery and application of cocamidopropyl betaine highlight its importance as a versatile and effective surfactant in both consumer and industrial products. Its ability to provide effective cleaning, foaming, and skin-friendly properties has made it a staple in the formulation of personal care products worldwide.

References

2024. Enhancing sludge thickening in continuous treatment using polymeric bubbles with cationic polymer P2900 and cocamidopropyl betaine. Environmental Science and Pollution Research, 31(47).
DOI: 10.1007/s11356-024-35100-0

2024. Safety assessment of cocamidopropyl betaine, a cosmetic ingredient. Toxicological Research, 40(3).
DOI: 10.1007/s43188-024-00243-2

2023. Transcriptomic analysis provides insights into the algicidal mechanism of cocamidopropyl betaine against the red tide microalgae Skeletonema costatum. Marine Environmental Research, 183.
DOI: 10.1016/j.marenvres.2022.105838