米泊美生
[CAS# 1000120-98-8]

基本信息

• 产品分类: 原料药 >> 循环系统用药
• 英文名: Mipomersen
• 别名: ISIS 301012 Parent Acid;[(3R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[(3R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[(2R,3R,5R)-3-[[(2R,3R,4S,5R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[(2R,3S,5R)-3-[[(2R,3S,5R)-3-[[(2R,3S,5R)-3-[[(2R,3S,5R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[(2R,3S,5R)-3-[[(2R,3S,5R)-3-[[(2R,3S,5R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[(2R,3S,5R)-3-[[(2R,3S,5R)-3-[[(2R,3S,5R)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[(2R,5R)-3-[[5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[3-[[5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-hydroxy-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(6-aminopurin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(2-amino-6-oxo-1H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(2-amino-6-oxo-1H-purin-9-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(2-amino-6-oxo-1H-purin-9-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-5-(6-aminopurin-9-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]sulfanyl-4-(2-methoxyethoxy)tetrahydrofuran-2-yl]methoxy-[(3R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl]sulfanyl-phosphinate
• 产品名称: 米泊美生
• 分子式: C₂₃₀H₃₀₅N₆₇O₁₂₂P₁₉S₁₉
• 分子量: 7157.99
• CAS 登录号: 1000120-98-8
• 分子行输入简码SMILES: Cc1cn(c(=O)[nH]c1=O)[C@H]2C[C@@H]([C@H](O2)COP(=O)([O-])S[C@H]3C[C@@H](O[C@@H]3COP(=O)([O-])S[C@H]4C[C@@H](O[C@@H]4COP(=O)([O-])S[C@H]5C[C@@H](O[C@@H]5COP(=O)([O-])S[C@H]6C[C@@H](O[C@@H]6COP(=O)([O-])S[C@H]7C[C@@H](O[C@@H]7COP(=O)([O-])S[C@H]8C[C@@H](O[C@@H]8COP(=O)([O-])S[C@H]9C[C@@H](O[C@@H]9COP(=O)([O-])S[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)n1cc(c(nc1=O)N)C)COP(=O)([O-])S[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)n1cc(c(=O)[nH]c1=O)C)COP(=O)([O-])S[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)n1cc(c(nc1=O)N)C)COP(=O)([O-])S[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)n1cc(c(nc1=O)N)C)COP(=O)([O-])S[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)n1cnc2c1nc([nH]c2=O)N)CO)n1cnc2c1ncnc2N)n1cnc2c1nc([nH]c2=O)N)n1cc(c(=O)[nH]c1=O)C)n1cc(c(nc1=O)N)C)n1cc(c(=O)[nH]c1=O)C)n1cnc2c1nc([nH]c2=O)N)n1cc(c(nc1=O)N)C)SP(=O)([O-])OC[C@@H]1[C@H](C[C@@H](O1)n1cc(c(=O)[nH]c1=O)C)SP(=O)([O-])OC[C@@H]1[C@H](C[C@@H](O1)n1cc(c(nc1=O)N)C)SP(=O)([O-])OC[C@@H]1[C@H]([C@H]([C@@H](O1)n1cnc2c1nc([nH]c2=O)N)OCCOC)SP(=O)([O-])OC[C@H]1[C@@H]([C@@H]([C@H](O1)n1cc(c(nc1=O)N)C)OCCOC)SP(=O)([O-])OC[C@H]1[C@@H]([C@@H]([C@H](O1)n1cnc2c1ncnc2N)OCCOC)SP(=O)([O-])OC[C@H]1[C@@H]([C@@H]([C@H](O1)n1cc(c(nc1=O)N)C)OCCOC)SP(=O)([O-])OC[C@H]1[C@@H]([C@@H]([C@H](O1)n1cc(c(nc1=O)N)C)OCCOC)O