(alphaR)-5-Amino-2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-alpha-[(phenylmethoxy)methyl]-1H-indole-1-ethanol
[CAS# 1294504-67-8]

Identification

• Classification: Organic raw materials >> Heterocyclic compound >> Indoles
• Name: (alphaR)-5-Amino-2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-alpha-[(phenylmethoxy)methyl]-1H-indole-1-ethanol
• Synonyms: (2R)-1-[5-amino-6-fluoro-2-(2-methyl-1-phenylmethoxypropan-2-yl)indol-1-yl]-3-phenylmethoxypropan-2-ol
• Molecular Formula: C₂₉H₃₃FN₂O₃
• Molecular Weight: 476.58
• CAS Registry Number: 1294504-67-8
• EC Number: 811-584-9
• SMILES: CC(C)(COCC1=CC=CC=C1)C2=CC3=CC(=C(C=C3N2C[C@H](COCC4=CC=CC=C4)O)F)N

Properties

• Solubility: Insoluble (1.0E^-3 g/L) (25 ºC), Calc.^*
• Density: 1.16±0.1 g/cm³ (20 ºC 760 Torr), Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P304+P340-P305+P351+P338-P319-P321-P330-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Discovory and Applicatios

(alphaR)-5-Amino-2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-alpha-[(phenylmethoxy)methyl]-1H-indole-1-ethanol is a complex organic compound that belongs to the class of indole derivatives. Indole-based compounds are known for their wide range of biological activities, making them significant in medicinal chemistry. This specific compound has gained attention due to its potential applications in drug discovery, particularly in targeting various physiological systems.

The discovery of (alphaR)-5-Amino-2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-alpha-[(phenylmethoxy)methyl]-1H-indole-1-ethanol stems from ongoing efforts to design novel bioactive molecules. The indole ring system is structurally versatile and can interact with various receptors and enzymes in the human body. The addition of a fluoro group at position 6 of the indole ring enhances the compound’s ability to interact with specific biological targets, potentially improving its potency and selectivity. The incorporation of phenylmethoxy and dimethyl groups in the side chains further fine-tunes the molecule’s bioactivity, making it a promising candidate for pharmaceutical development.

The primary application of (alphaR)-5-Amino-2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-alpha-[(phenylmethoxy)methyl]-1H-indole-1-ethanol lies in its potential as a therapeutic agent. Researchers have explored its interactions with neurotransmitter systems, particularly in relation to the central nervous system. Compounds with indole-based structures are often investigated for their effects on serotonin receptors, which play a crucial role in mood regulation, cognition, and various neuropsychiatric disorders. Given the structure of this compound, it is hypothesized that it may act as a selective modulator of serotonin pathways, offering therapeutic potential for treating conditions such as depression, anxiety, and other mood disorders.

In addition to its potential neuropharmacological applications, the compound’s unique structural features make it suitable for exploring other therapeutic areas, including oncology and immunology. The fluoro and phenylmethoxy groups may contribute to increased metabolic stability and improved bioavailability, which are critical factors in drug development. This compound could be further modified to enhance its efficacy, specificity, and pharmacokinetic properties.

Ongoing research on (alphaR)-5-Amino-2-[1,1-dimethyl-2-(phenylmethoxy)ethyl]-6-fluoro-alpha-[(phenylmethoxy)methyl]-1H-indole-1-ethanol is focused on its mechanistic pathways, receptor interactions, and in vivo efficacy. The compound serves as an important lead in the development of novel drugs with applications in mental health, cancer, and immune modulation.