4-Chlorophenyl-2-pyridinylmethanol
[CAS# 27652-89-7]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyridine compound
• Name: 4-Chlorophenyl-2-pyridinylmethanol
• Synonyms: alpha-(4-Chlorophenyl)pyridine-2-methanol
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• CAS Registry Number: 27652-89-7
• EC Number: 248-592-1
• SMILES: C1=CC=NC(=C1)C(C2=CC=C(C=C2)Cl)O

Properties

• Density: 1.3±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.615, Calc.^*
• Boiling Point: 364.3±32.0 ºC (760 mmHg), Calc.^*
• Flash Point: 174.1±25.1 ºC, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302
• Precautionary Statements: P264-P270-P301+P317-P330-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H332
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovory and Applicatios

4-Chlorophenyl-2-pyridinylmethanol is a chemical compound that has garnered interest in the fields of organic chemistry and medicinal chemistry due to its unique structure and potential biological activity. This compound consists of a pyridine ring, a chlorophenyl group, and a hydroxymethyl group. The combination of these structural elements contributes to the compound's versatility and potential for interaction with various biological systems.

The discovery of 4-Chlorophenyl-2-pyridinylmethanol is part of ongoing research aimed at developing new chemical entities with various applications. The chlorophenyl group, which is commonly found in many biologically active molecules, may play a significant role in modulating the compound's interaction with specific targets such as receptors or enzymes. The pyridine ring is also an important structural component in many pharmaceutical agents, often contributing to the compound's ability to interact with biologically relevant systems.

One of the primary areas of interest for 4-Chlorophenyl-2-pyridinylmethanol is its potential as a drug candidate. The hydroxymethyl group can serve as a key functional moiety for enhancing the compound's interaction with biological targets. This group could influence the molecule's ability to form hydrogen bonds or interact with proteins, making it a valuable building block in drug design. The presence of both a pyridine ring and a chlorophenyl group suggests that this compound may exhibit activity against various biological pathways, including those involved in inflammation, neurological disorders, or cancer.

Moreover, 4-Chlorophenyl-2-pyridinylmethanol may have applications in the development of compounds that target specific receptors or enzymes. Pyridine-based compounds have been studied for their ability to interact with nicotinic acetylcholine receptors, which are involved in various neurological functions. Additionally, the chlorophenyl group could enhance the compound's binding affinity to specific enzymes or receptors, making it a promising candidate for further exploration in drug discovery.

The compound’s potential as a synthetic intermediate in the production of other biologically active compounds further contributes to its importance. As a versatile building block, 4-Chlorophenyl-2-pyridinylmethanol can be used in the synthesis of more complex molecules with targeted pharmacological profiles. Researchers may explore its use in the design of molecules with specific activity against a range of diseases, including cancer, Alzheimer's disease, and other conditions involving neuronal signaling.

Future research into 4-Chlorophenyl-2-pyridinylmethanol will focus on its pharmacological properties, including its ability to interact with specific receptors or enzymes, its bioavailability, and its potential for therapeutic use. Optimizing the structure of this compound to enhance its selectivity and potency against desired targets will be crucial in determining its clinical potential. As part of ongoing efforts to develop new and effective therapeutic agents, 4-Chlorophenyl-2-pyridinylmethanol represents an exciting opportunity for drug discovery and development.

References

2019. Efficient synthesis of an antiviral drug intermediate using an enhanced short-chain dehydrogenase in an aqueous-organic solvent system. Applied Microbiology and Biotechnology.
DOI: 10.1007/s00253-019-09781-4

2011. Diaryl Ketones. Science of Synthesis.
URL: https://science-of-synthesis.thieme.com/app/text/?id=SD-202-00066

2003. Bepotastine besilate. Pharmaceutical Substances.
URL: https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-02-0062