Category of Chemicals

Mdm2 inhibitors are essential in cancer treatment. They target Mdm2, a protein that inhibits the activity of the p53 tumor suppressor. By blocking Mdm2, these drugs unleash p53's power to halt cancer growth and initiate apoptosis, specifically in tumors with intact p53 pathways. Nutlin-3 is a notable example, showing promise in various preclinical and clinical studies.