Mdm2 activators are compounds that interact with Mdm2, a crucial regulator of the tumor suppressor protein p53. These activators promote the binding of Mdm2 to p53, facilitating p53 degradation. In certain cancer types where p53 is overexpressed, these activators hold promise for restoring proper p53 regulation and potentially inhibiting cancer growth. They represent a potential avenue for cancer therapy, particularly for tumors driven by p53 dysregulation.
