Category of chemicals: CRM1 inhibitor

CRM1 inhibitors are a class of compounds designed to disrupt the function of Chromosome Region Maintenance 1 (CRM1) protein. This protein plays a crucial role in regulating the movement of proteins and RNAs between the cell nucleus and cytoplasm. Inhibiting CRM1 can halt the inappropriate export of tumor suppressor proteins, contributing to the development of potential cancer therapies. These inhibitors have garnered significant interest in cancer research as they hold promise for blocking this uncontrolled cellular transport and inhibiting cancer growth.

Products of CRM1 inhibitor
CAS No.	Product Name	Molecular Formula
1333151-73-7	(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester	C₁₆H₁₆F₃N₃O₃
1392136-43-4	Verdinexor	C₁₈H₁₂F₆N₆O
1393477-72-9	KPT 330	C₁₇H₁₁F₆N₇O
1421919-75-6	(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-2-propen-1-one	C₁₆H₁₀F₈N₄O

Products of CRM1 inhibitor

CAS No.

Product Name

Molecular Formula

1333151-73-7

(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester

C₁₆H₁₆F₃N₃O₃

1392136-43-4

Verdinexor

C₁₈H₁₂F₆N₆O

1393477-72-9

KPT 330

C₁₇H₁₁F₆N₇O

1421919-75-6

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-2-propen-1-one

C₁₆H₁₀F₈N₄O