Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) activators are a promising development in the treatment of cystic fibrosis (CF). CF is a genetic disorder that affects the lungs and digestive system. CFTR activators work by increasing the function of the defective CFTR protein, thereby improving the flow of salt and fluids across cell membranes. This helps maintain proper hydration in the airway and other affected organs. By addressing the root cause of the disease at a molecular level, CFTR activators are transforming the management of CF, offering patients improved quality of life and extended life expectancy.