Category of chemicals: TGF-beta/Smad inhibitor

Transforming Growth Factor-beta (TGF-beta) plays a dual role in the body - it regulates tissue repair but also contributes to fibrosis and cancer when dysregulated. TGF-beta/Smad inhibitors are a class of drugs designed to interfere with these signaling pathways, potentially halting or reversing fibrosis and preventing cancer progression. These inhibitors hold promise for various conditions, from liver fibrosis to certain cancers, offering a new frontier in treating diseases characterized by excessive tissue remodeling.

Products of TGF-beta/Smad inhibitor
CAS No.	Product Name	Molecular Formula
1062368-24-4	LDN 193189	C₂₅H₂₂N₆
1062368-49-3	LDN 193719	C₂₂H₁₆N₄O
1062368-62-0	4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride (1:1)	C₂₅H₂₂N₆.HCl
1206711-16-1	4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	C₂₄H₂₀N₄O
1352608-82-2	N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline	C₂₂H₁₈FN₇
1431985-92-0	3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol	C₂₀H₂₀N₂O₄
1432597-26-6	5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline	C₂₅H₂₂N₆
1627503-67-6	1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine	C₂₅H₂₉N₃O₃
301836-41-9	SB 431542	C₂₂H₁₆N₄O₃
356559-20-1	SB 525334	C₂₁H₂₁N₅
396129-53-6	4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline	C₁₇H₁₂N₄
446859-33-2	RepSox	C₁₇H₁₃N₅
452342-67-5	GW 788388	C₂₅H₂₃N₅O₂
627536-09-8	SCI 208	C₁₇H₁₀ClFN₆
694433-59-5	2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine	C₂₀H₂₁N₃O₂
700874-71-1	LY 2109761	C₂₆H₂₇N₅O₂
700874-72-2	LY 2157299	C₂₂H₁₉N₅O

Products of TGF-beta/Smad inhibitor

CAS No.

Product Name

Molecular Formula

1062368-24-4

LDN 193189

C₂₅H₂₂N₆

1062368-49-3

LDN 193719

C₂₂H₁₆N₄O

1062368-62-0

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride (1:1)

C₂₅H₂₂N₆.HCl

1206711-16-1

4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

C₂₄H₂₀N₄O

1352608-82-2

N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline

C₂₂H₁₈FN₇

1431985-92-0

3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol

C₂₀H₂₀N₂O₄

1432597-26-6

5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

C₂₅H₂₂N₆

1627503-67-6

1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine

C₂₅H₂₉N₃O₃

301836-41-9

SB 431542

C₂₂H₁₆N₄O₃

356559-20-1

SB 525334

C₂₁H₂₁N₅

396129-53-6

4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline

C₁₇H₁₂N₄

446859-33-2

RepSox

C₁₇H₁₃N₅

452342-67-5

GW 788388

C₂₅H₂₃N₅O₂

627536-09-8

SCI 208

C₁₇H₁₀ClFN₆

694433-59-5

2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine

C₂₀H₂₁N₃O₂

700874-71-1

LY 2109761

C₂₆H₂₇N₅O₂

700874-72-2

LY 2157299

C₂₂H₁₉N₅O

Category of Chemicals

TGF-beta/Smad inhibitor