Category of chemicals: Hedgehog/Smoothened antagonist

Hedgehog/Smoothened antagonists are a class of compounds designed to inhibit the Hedgehog signaling pathway. This pathway plays a pivotal role in embryonic development and tissue regeneration, and its dysregulation is associated with various cancers, including basal cell carcinoma. By blocking the pathway's key components, such as Smoothened, these antagonists show potential in treating cancers driven by abnormal Hedgehog signaling. They're a promising area of research in the quest for innovative cancer therapies and could have applications in various other medical conditions connected to Hedgehog pathway dysfunction.

Products of Hedgehog/Smoothened antagonist
CAS No.	Product Name	Molecular Formula
1059734-66-5	N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide	C₃₀H₂₇N₅O
1373615-35-0	1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-1-piperazinyl]-3-(methylsulfonyl)-1-propanone	C₂₀H₂₅ClN₄O₃S
304909-07-7	(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine	C₂₃H₂₇N₅
4449-51-8	Cyclopamine	C₂₇H₄₁NO₂
956697-53-3	Erismodegib	C₂₆H₂₆F₃N₃O₃

Products of Hedgehog/Smoothened antagonist

CAS No.

Product Name

Molecular Formula

1059734-66-5

N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide

C₃₀H₂₇N₅O

1373615-35-0

1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-1-piperazinyl]-3-(methylsulfonyl)-1-propanone

C₂₀H₂₅ClN₄O₃S

304909-07-7

(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine

C₂₃H₂₇N₅

4449-51-8

Cyclopamine

C₂₇H₄₁NO₂

956697-53-3

Erismodegib

C₂₆H₂₆F₃N₃O₃