Hedgehog/Smoothened Agonists are compounds that activate the Hedgehog/Smoothened signaling pathway. This pathway is essential in embryonic development, tissue repair, and regeneration. By promoting the pathway's activity, these agonists have potential therapeutic applications in regenerative medicine and tissue repair processes. However, their use and development require careful consideration due to the pathway's role in various diseases, especially cancers, where its activation can lead to uncontrolled cell growth.