NF-κB inhibitors are a class of molecules that target the NF-κB (Nuclear Factor-kappa B) pathway, a key regulator of immune and inflammatory responses. By blocking NF-κB activation, these inhibitors can help mitigate excessive inflammation and immune system activity, making them potential candidates for treating various inflammatory conditions, autoimmune diseases, and even some cancers where NF-κB is overactive. Careful application is necessary as they can weaken the immune response, potentially rendering the body more susceptible to infections.