Butylamine
[CAS# 109-73-9]

Identification

• Classification: Organic raw materials >> Amino compound >> Acyclic monoamines, polyamines and their derivatives and salts
• Name: Butylamine
• Synonyms: 1-Aminobutane; 1-Butanamine; n-Butylamine
• Molecular Formula: C₄H₁₁N
• Molecular Weight: 73.14
• CAS Registry Number: 109-73-9
• EC Number: 203-699-2
• FEMA: 3130
• SMILES: CCCCN

Properties

• Density: 0.741
• Melting point: -49 °C
• Boiling point: 78 °C
• Refractive index: 1.4-1.402
• Flash point: -7 °C
• Water solubility: MISCIBLE

Safety Data

• Hazard Symbols: GHS02;GHS05;GHS06;GHS07 Danger
• Risk Statements: H225-H302-H311-H312-H314-H318-H330-H331-H332-H335
• Safety Statements: P210-P233-P240-P241-P242-P243-P260-P261-P262-P264-P264+P265-P270-P271-P280-P284-P301+P317-P301+P330+P331-P302+P352-P302+P361+P354-P303+P361+P353-P304+P340-P305+P354+P338-P316-P317-P319-P320-P321-P330-P361+P364-P362+P364-P363-P370+P378-P403+P233-P403+P235-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Flammable liquids	Flam. Liq.	2	H225
Skin corrosion	Skin Corr.	1A	H314
Acute toxicity	Acute Tox.	4	H312
Acute toxicity	Acute Tox.	4	H332
Acute toxicity	Acute Tox.	3	H311
Specific target organ toxicity - single exposure	STOT SE	3	H335
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	2	H330
Acute toxicity	Acute Tox.	3	H331
Substances or mixtures corrosive to metals	Met. Corr.	1	H290
Reproductive toxicity	Repr.	1B	H360
Skin corrosion	Skin Corr.	1B	H314

• Transport Information: UN 1125

Discovery and Applications

Butylamine is an organic compound belonging to the family of aliphatic amines, with the molecular formula C4H11N. It exists as a colorless liquid with a strong ammonia-like odor and is miscible with water and organic solvents. The discovery of butylamine can be traced back to the early exploration of amine chemistry, where the compound was synthesized through the reaction of butyl halides with ammonia. As the chemical industry expanded, butylamine gained significance due to its role as a precursor in various industrial processes.

One of the main applications of butylamine is in the production of pharmaceuticals. It serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its primary amine group makes it a versatile building block in organic synthesis, allowing for the production of various drug compounds, including antiviral, antihypertensive, and anti-inflammatory medications. Butylamine’s role in pharmaceutical manufacturing underscores its importance in modern medicine.

Butylamine is also widely used in the production of pesticides and herbicides in the agrochemical industry. It is employed in the synthesis of active ingredients that control pests and weeds, contributing to improved crop yields and food security. Its reactivity allows it to form amides and other nitrogen-containing compounds that are essential in agricultural chemicals.

In the rubber industry, butylamine is utilized in the production of rubber accelerators. These accelerators enhance the vulcanization process, improving the physical properties of rubber products such as elasticity, durability, and resistance to wear. Butylamine-based accelerators are crucial in manufacturing tires, hoses, and various other rubber goods.

Additionally, butylamine is used as a solvent and corrosion inhibitor in different industrial applications. Its ability to act as a stabilizer and improve the longevity of materials makes it valuable in the production of coatings, lubricants, and other protective solutions.

References

2018. Biocatalytic concepts for synthesizing amine bulk chemicals: recent approaches towards linear and cyclic aliphatic primary amines and ω-substituted derivatives thereof. Applied Microbiology and Biotechnology.
DOI: 10.1007/s00253-018-9452-0

2012. Reactions of Organic Ions at Ambient Surfaces in a Solvent-Free Environment. Journal of The American Society for Mass Spectrometry.
DOI: 10.1007/s13361-012-0337-7

2004. Studies on Tellurium-Containing Heterocycles. Part 20. Reactions of 2-Benzoselenopyrylium Salts and 2-Benzotelluropyrylium Salts with Nucleophiles: Formation of 1-Functionalized 1H-Isoselenochromenes and 1H-Isotellurochromenes. Chemical and Pharmaceutical Bulletin.
DOI: 10.1248/cpb.52.57