3-Amino-2-fluorobenzoic acid methyl ester
[CAS# 1195768-18-3]

Identification

• Classification: Pharmaceutical intermediate >> API intermediate
• Name: 3-Amino-2-fluorobenzoic acid methyl ester
• Synonyms: Methyl 2-fluoro-3-aminobenzoate; Methyl 3-amino-2-fluorobenzoate
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169.15
• CAS Registry Number: 1195768-18-3
• EC Number: 629-868-4
• SMILES: COC(=O)C1=C(C(=CC=C1)N)F

Properties

• Solubility: Slightly soluble (1.6 g/L) (25 °C), Calc.^*
• Density: 1.264±0.06 g/cm³ (20 °C 760 Torr), Calc.^*
• Boiling point: 282.6±25.0 °C (760 Torr), Calc.^*
• Flash point: 124.7±23.2 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2015 ACD/Labs)

Safety Data

• Hazard Symbols: GHS02;GHS05;GHS07 Danger
• Risk Statements: H226-H302--H315-H318-H319-H335
• Safety Statements: P210-P233-P240-P241-P242-P243-P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P305+P354+P338-P317-P319-P321-P330-P332+P317-P337+P317-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Flammable liquids	Flam. Liq.	3	H226
Eye irritation	Eye Irrit.	2A	H319
Acute toxicity	Acute Tox.	4	H302
Specific target organ toxicity - single exposure	STOT SE	3	H335
Serious eye damage	Eye Dam.	1	H318
Eye irritation	Eye Irrit.	2	H319

Discovery and Applications

3-Amino-2-fluorobenzoic acid methyl ester is an organic compound that has garnered interest primarily in the field of medicinal chemistry. The discovery and synthesis of this compound stem from efforts to explore fluorinated aromatic compounds, which are known for their enhanced biological activity and stability. It was synthesized through a series of chemical reactions starting from fluorinated benzene derivatives, employing standard esterification and amination techniques. The addition of the fluorine atom is particularly significant as it can influence the compound's electronic properties, potentially enhancing its pharmacological profile. Although not a blockbuster compound in itself, 3-amino-2-fluorobenzoic acid methyl ester serves as a crucial intermediate in the development of various pharmaceuticals and agrochemicals.

The primary applications of 3-amino-2-fluorobenzoic acid methyl ester lie in its role as an intermediate in the synthesis of more complex organic molecules. Its structural characteristics make it a valuable building block in the development of pharmaceuticals, particularly in drug discovery and design. The fluorine atom in the compound can significantly enhance the biological activity of pharmaceuticals by increasing their binding affinity to target proteins, improving metabolic stability, and modulating lipophilicity. This makes the compound particularly useful in the design of enzyme inhibitors and receptor antagonists.

In medicinal chemistry, 3-amino-2-fluorobenzoic acid methyl ester is utilized to synthesize a variety of active pharmaceutical ingredients (APIs). For example, it can be incorporated into molecules aimed at treating conditions such as cancer, bacterial infections, and neurological disorders. Its incorporation into drug molecules can enhance their efficacy and reduce unwanted side effects. Additionally, the amino group in the compound allows for further chemical modifications, facilitating the creation of diverse molecular libraries for high-throughput screening in drug discovery processes.

Beyond pharmaceuticals, 3-amino-2-fluorobenzoic acid methyl ester also finds applications in the agrochemical industry. It serves as a precursor in the synthesis of herbicides and pesticides, where the fluorine atom helps improve the bioactivity and environmental stability of these compounds. The ester functionality can be hydrolyzed under certain conditions to yield the corresponding acid, which can further react with various agents to form active agrochemical ingredients.

Moreover, this compound is valuable in materials science for the development of novel polymers and advanced materials. The presence of fluorine can enhance the thermal stability and chemical resistance of these materials, making them suitable for a wide range of industrial applications.

References

2014. Dabrafenib. Pharmaceutical Substances.
URL: https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-04-0183