(S)-Methyl 3-amino-3-(4-chlorophenyl)propanoate hydrochloride
[CAS# 1217775-76-2]

Identification

• Classification: Biochemical >> Amino acids and their derivatives
• Name: (S)-Methyl 3-amino-3-(4-chlorophenyl)propanoate hydrochloride
• Synonyms: methyl (3S)-3-amino-3-(4-chlorophenyl)propanoate;hydrochloride
• Molecular Formula: C₁₀H₁₃Cl₂NO₂
• Molecular Weight: 250.12
• Protein Sequence: X
• CAS Registry Number: 1217775-76-2
• EC Number: 893-521-5
• SMILES: COC(=O)C[C@@H](C1=CC=C(C=C1)Cl)N.Cl

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H335
• Safety Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2A	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335

Discovery and Applications

(S)-Methyl 3-amino-3-(4-chlorophenyl)propanoate hydrochloride is a chiral amino acid derivative with significant applications in pharmaceutical synthesis. The discovery of this compound stems from the need to develop enantiomerically pure intermediates for the production of bioactive molecules. Its structure, featuring a chlorophenyl group and an amino acid backbone, is particularly valuable for creating selective and potent therapeutic agents.

The synthesis of (S)-Methyl 3-amino-3-(4-chlorophenyl)propanoate hydrochloride involves the asymmetric hydrogenation of α-keto esters using chiral catalysts. This method ensures high enantioselectivity and yield, providing a reliable route to obtain the (S)-enantiomer. The hydrochloride salt form enhances the compound's stability and solubility, facilitating its use in subsequent chemical reactions.

This compound plays a crucial role in the development of drugs targeting neurological and cardiovascular disorders. It serves as a key intermediate in the synthesis of inhibitors for enzymes such as proteases and kinases, which are implicated in various disease pathways. Its structural motif is also explored in the design of anticonvulsant and analgesic agents, demonstrating broad pharmaceutical potential.

Ongoing research continues to investigate novel applications for (S)-Methyl 3-amino-3-(4-chlorophenyl)propanoate hydrochloride in medicinal chemistry. Its incorporation into drug discovery pipelines highlights the importance of chiral intermediates in modern drug development, underscoring the value of stereochemistry in achieving desired pharmacological effects.

References

none