Zinc dipyroglutamate
[CAS# 15454-75-8]

Identification

• Classification: Biochemical >> Amino acids and their derivatives >> Glutamic acid derivative
• Name: Zinc dipyroglutamate
• Synonyms: Zinc L-pyroglutamate; Zinc PCA; Bis(5-oxo-L-prolinato)zinc
• Molecular Formula: C₁₀H₁₂N₂O₆Zn
• Molecular Weight: 321.59
• CAS Registry Number: 15454-75-8
• EC Number: 239-473-5
• SMILES: C1CC(=O)NC1C(=O)[O-].C1CC(=O)NC1C(=O)[O-].[Zn+2]

Safety Data

• Hazard Symbols: GHS05 Danger
• Risk Statements: H318
• Safety Statements: P264+P265-P280-P305+P354+P338-P317

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318
Eye irritation	Eye Irrit.	2	H319

• Transport Information: UN 1759

Discovery and Applications

Zinc dipyroglutamate is a notable chemical compound that has garnered attention in both medicinal chemistry and nutritional science due to its unique properties and potential applications. This compound consists of zinc coordinated with dipyroglutamate, a derivative of pyroglutamic acid, which is an amino acid widely studied for its role in biochemical processes.

The discovery of zinc dipyroglutamate can be traced to research focused on the complexation of zinc with various amino acid derivatives. Pyroglutamic acid, known for its role in protein metabolism and cellular function, has been utilized to form coordination compounds with zinc to enhance the stability and bioavailability of the metal ion. Zinc dipyroglutamate emerged from these studies as a compound with promising properties for several applications.

In medicinal chemistry, zinc dipyroglutamate is explored for its potential therapeutic benefits. Zinc is an essential trace element that plays a critical role in numerous enzymatic reactions, immune function, and cellular repair. By coordinating zinc with dipyroglutamate, researchers aim to improve the delivery and efficacy of zinc in therapeutic applications. The compound's formulation is designed to enhance zinc's bioavailability, ensuring that it is more effectively absorbed and utilized by the body.

One significant application of zinc dipyroglutamate is in the field of dietary supplements. Zinc supplementation is commonly used to address deficiencies and support overall health, particularly in immune system function and wound healing. Zinc dipyroglutamate, with its enhanced bioavailability compared to other zinc compounds, is used in supplements to provide a more efficient source of zinc. The compound's stability and solubility in various formulations make it a favorable choice for inclusion in health products.

Additionally, zinc dipyroglutamate is investigated for its potential use in skincare and cosmetic formulations. Zinc is known for its beneficial effects on skin health, including its anti-inflammatory and antimicrobial properties. By incorporating zinc dipyroglutamate into skincare products, manufacturers aim to leverage its properties for improved skin care benefits. The compound's ability to deliver zinc in a stable and effective form can enhance the efficacy of cosmetic formulations designed to address skin issues such as acne and inflammation.

Research into zinc dipyroglutamate continues to expand, focusing on optimizing its applications and understanding its interactions in biological systems. The compound's role in enhancing zinc delivery and its potential benefits in health and skincare underscore its significance in both scientific research and practical applications.

References

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