10-Hydroxydecanoic acid
[CAS# 1679-53-4]

Identification

• Classification: Chemical reagent >> Organic reagent >> Fatty acid
• Name: 10-Hydroxydecanoic acid
• Molecular Formula: C₁₀H₂₀O₃
• Molecular Weight: 188.27
• CAS Registry Number: 1679-53-4
• EC Number: 216-848-1
• SMILES: C(CCCCC(=O)O)CCCCO

Properties

• Solubility: 2672 mg/L (25 °C water)
• Density: 1.0±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.466, Calc.^*
• Melting point: 103.74 °C
• Boiling Point: 330.8±15.0 °C (760 mmHg), Calc.^*, 332.10 °C
• Flash Point: 168.1±16.9 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H335
• Safety Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Eye irritation	Eye Irrit.	2	H319
Eye irritation	Eye Irrit.	2A	H319

Discovery and Applications

10-Hydroxydecanoic acid, also known as 10-HDA, is a natural fatty acid found in royal jelly produced by bees. 10-HDA was first identified and isolated from royal jelly in the mid-20th century through chemical analysis and characterization techniques. It is a medium chain fatty acid with the hydroxyl group located at the tenth carbon position of the carbon chain.

Studies have shown that 10-HDA has a variety of pharmacological activities, including antibacterial, anti-inflammatory, antioxidant and immunomodulatory effects. As a result, 10-HDA has been investigated for its potential applications in the treatment of infectious diseases, inflammation, oxidative stress-related diseases, and immune system dysfunction. 10-Hydroxydecanoic acid is widely used in the cosmetic industry for its skin care benefits and cosmetic properties. Due to its moisturizing and emollient properties, 10-HDA is often added to skin care products such as creams, lotions, serums, and moisturizers to moisturize and soften the skin. 10-Hydroxydecanoic acid is considered a functional food ingredient with potential health-promoting properties. It is often included in dietary supplements and functional foods to support immunity, cardiovascular health and overall health. In addition to pharmaceutical and cosmetic applications, 10-hydroxydecanoic acid is used as a research tool in various biomedical studies and experiments. Researchers studied its biological activity, mode of action, and potential therapeutic applications in preclinical and clinical settings. 10-Hydroxydecanoic acid is an important chemical component of royal jelly and a valuable product of beekeeping. The presence of 10-HDA in royal jelly helps to enhance its nutritional value and biological properties, supporting the growth, development and health of bee colonies.

References

2024. Anti-inflammatory effects of 10-hydroxydecanoic acid in experimental models. Journal of Neuroinflammation, 21(1).
DOI: 10.1186/s12974-024-03177-6

2023. Recent advances in the synthesis and biological applications of 10-hydroxydecanoic acid. Metabolomics, 19(10).
DOI: 10.1007/s11306-023-02039-1

2019. Chemical synthesis and antimicrobial properties of 10-hydroxydecanoic acid derivatives. Apidologie, 50(5).
DOI: 10.1007/s13592-019-00709-5