Ceramide np
[CAS# 178436-06-1]

Identification

• Classification: Organic raw materials >> Amino compound >> Amide compound
• Name: Ceramide np
• Synonyms: (Z)-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadec-9-enamide
• Molecular Formula: C₃₆H₇₁NO₄
• Molecular Weight: 581.95
• CAS Registry Number: 178436-06-1
• EC Number: 812-963-1
• SMILES: CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)CCCCCCC/C=CCCCCCCCC)O)O

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P280-P301+P312-P302+P352-P305+P351+P338

Discovery and Applications

Ceramide NPs are synthetic analogs of natural ceramides that have revolutionized skincare and dermatology. Ceramides are lipid molecules that are essential for maintaining the skin barrier and retaining moisture. The discovery and application of ceramide NPs offer significant advances in treating a variety of skin conditions and improving overall skin health.

Ceramide NPs stem from extensive research into the skin’s lipid barrier. Natural ceramides, specifically ceramide 2 (also known as ceramide NPs), are believed to be essential for skin hydration and integrity. Scientists aimed to create a stable, effective synthetic version to enhance skincare formulations.

The development of ceramide NPs involves synthesizing a molecule that mimics the structure and function of natural ceramides. This synthetic version ensures stability, longer shelf life, and consistent performance in a variety of formulations, addressing the limitations of natural ceramides.

Ceramide NPs work by strengthening the skin’s natural barrier, helping to retain moisture and protect against environmental aggressors. It plays a vital role in preventing transepidermal water loss (TEWL), which can lead to dry, irritated, and sensitive skin. By mimicking natural ceramides, ceramide NPs help maintain lipid balance and promote smoother, more elastic skin.

One of the outstanding benefits of ceramide NPs is its ability to restore the skin's barrier function. This restoration is particularly beneficial for people with a compromised skin barrier, such as those with eczema, psoriasis, or aging skin. Incorporating ceramide NPs into skincare can significantly improve skin hydration, elasticity, and overall appearance.

The range of applications for ceramide NPs in skincare is wide and varied. It is often found in moisturizers, serums, and treatments designed to repair and strengthen the skin barrier. Due to its moisturizing properties, ceramide NPs are a popular ingredient in products for dry and sensitive skin.

In anti-aging formulations, ceramide NPs help fight visible signs of aging by enhancing skin hydration and firmness. It also works synergistically with other ingredients, such as hyaluronic acid and peptides, to provide comprehensive skin benefits.

References

2017. Chitosan-ceramide coating on gold nanorod to improve its physiological stability and reduce the lipid surface-related toxicity. Archives of Pharmacal Research.
DOI: 10.1007/s12272-017-0888-z

2015. Safety and risk assessment of ceramide 3 in cosmetic products. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
DOI: 10.1016/j.fct.2015.07.012

2014. Self-assembled Chitosan-Ceramide Nanoparticle for Enhanced Oral Delivery of Paclitaxel. Pharmaceutical Research.
DOI: 10.1007/s11095-014-1395-2