Ceramide AP
[CAS# 212070-45-6]

Identification

• Classification: Organic raw materials >> Amino compound >> Amide compound
• Name: Ceramide AP
• Synonyms: N-(2-hydroxyoctadecanoyl)-hydroxysphinganine
• Molecular Formula: C₃₆H₇₃NO₅
• Molecular Weight: 599.97
• CAS Registry Number: 212070-45-6
• EC Number: 936-560-6
• SMILES: CCCCCCCCCCCCCCCCC(C(=O)N[C@@H](CO)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)O

Discovery and Applications

Ceramide AP is a synthetic analog of natural ceramides that has made a significant impact in the skincare and dermatology fields. Ceramides are lipid molecules found in large quantities in the outer layer of the skin and play a vital role in maintaining the skin barrier function and retaining moisture. The discovery and application of Ceramide AP has enhanced our ability to treat a variety of skin conditions and improve overall skin health.

Ceramide AP was discovered through extensive research into the composition and function of the skin lipid barrier. Natural ceramides are considered key components in maintaining the moisture and integrity of the skin. Scientists aimed to create synthetic versions of these ceramides to ensure the stability and efficacy of skincare formulations.

The development of Ceramide AP involved the synthesis of a molecule that is very similar in structure and function to natural ceramides. This synthetic version offers several benefits, including enhanced stability, longer shelf life, and consistent performance in a variety of formulations.

Ceramide AP works by strengthening the skin's natural barrier, helping to retain moisture and protect against environmental aggressors. It is essential in preventing transepidermal water loss (TEWL), which can lead to dry, irritated, and sensitive skin. By mimicking natural ceramides, Ceramide AP helps maintain lipid balance, promoting smoother, more elastic skin.

One of the standout benefits of Ceramide AP is its ability to restore the skin's barrier function. This restoration is particularly beneficial for people with a compromised skin barrier, such as those with eczema, psoriasis, or aging skin. Incorporating Ceramide AP into skincare can significantly improve skin hydration, elasticity, and overall appearance.

The range of applications for Ceramide AP in skincare is wide and varied. It is often found in moisturizers, serums, and treatments designed to repair and strengthen the skin barrier. Ceramide AP is a popular ingredient in products for dry and sensitive skin due to its moisturizing properties.

In anti-aging formulations, Ceramide AP helps fight visible signs of aging by enhancing skin hydration and firmness. It also works synergistically with other ingredients, such as hyaluronic acid and peptides, to provide comprehensive skin benefits.

References

2012. Lecithin-Based Microemulsions for Targeted Delivery of Ceramide AP into the Stratum Corneum: Formulation, Characterizations, and In Vitro Release and Penetration Studies. Pharmaceutical Research, 30(2).
DOI: 10.1007/s11095-012-0899-x

2019. Role of Ceramides in Drug Delivery. AAPS PharmSciTech, 20(7).
DOI: 10.1208/s12249-019-1497-6

2016. Lipidomic platform for structural identification of skin ceramides with α-hydroxyacyl chains. Analytical and Bioanalytical Chemistry, 408(8).
DOI: 10.1007/s00216-015-9239-4