Esomeprazole magnesium trihydrate
[CAS# 217087-09-7]

Identification

• Classification: API >> Digestive system medication
• Name: Esomeprazole magnesium trihydrate
• Synonyms: Bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzylimidazole-1-yl) magnesium trihydrate
• Molecular Formula: 2(C₁₇H₁₈N₃O₃S).Mg.3(H₂O)
• Molecular Weight: 767.17
• CAS Registry Number: 217087-09-7
• EC Number: 669-839-3
• SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.O.O.O.[Mg+2]

Safety Data

• Hazard Symbols: GHS07;GHS09 Warning
• Risk Statements: H302-H317-H319-H411
• Safety Statements: P261-P264-P270-P271-P272-P280-P301+P317-P302+P352-P304+P340-P317-P321-P330-P333+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Skin sensitization	Skin Sens.	1	H317
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Eye irritation	Eye Irrit.	2	H319
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin irritation	Skin Irrit.	2	H315

Discovery and Applications

Esomeprazole magnesium trihydrate is a chemical compound introduced as a pharmaceutical agent in the early 2000s. It is a derivative of esomeprazole, a proton pump inhibitor (PPI) that is utilized primarily for its potent acid-reducing properties. Esomeprazole magnesium trihydrate is specifically used to manage conditions related to excessive stomach acid production.

The discovery of esomeprazole magnesium trihydrate stemmed from the need to develop more effective treatments for gastroesophageal reflux disease (GERD) and other acid-related disorders. As a PPI, it works by inhibiting the proton pumps in the stomach lining, which are responsible for the secretion of hydrochloric acid. By reducing acid production, esomeprazole magnesium trihydrate alleviates symptoms such as heartburn, acid reflux, and stomach ulcers, and promotes healing of the esophagus lining in cases of damage caused by excessive acid.

One of the primary applications of esomeprazole magnesium trihydrate is in the treatment of GERD, a chronic condition where stomach acid frequently leaks into the esophagus, causing discomfort and potential damage. The compound is also used to treat peptic ulcers and Zollinger-Ellison syndrome, a condition characterized by excessive stomach acid production. It is available in various forms, including oral tablets and intravenous solutions, allowing for flexible administration depending on patient needs.

In addition to its therapeutic uses, esomeprazole magnesium trihydrate is studied for its potential benefits in combination therapies. For instance, it is often used in conjunction with antibiotics to eradicate Helicobacter pylori, a bacterium associated with stomach ulcers. The compound's effectiveness in reducing stomach acid enhances the efficacy of antibiotic treatment by creating a less acidic environment that allows the antibiotics to work more effectively.

Esomeprazole magnesium trihydrate has been well-received in clinical practice due to its efficacy and safety profile. However, as with any medication, it is important to use it under medical supervision to manage potential side effects and interactions with other drugs.

References

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