Poly(ethylene glycol)
[CAS# 25322-68-3]

Identification

• Classification: Catalysts and additives >> Polyethylene glycol derivative
• Name: Poly(ethylene glycol)
• Synonyms: Polyethylene glycol; PEG
• CAS Registry Number: 25322-68-3 (6812-36-8)
• EC Number: 640-029-1

Properties

• Density: 1.125
• Melting point: -65 °C
• Refractive index: 1.458-1.461
• Flash point: 171 °C

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P305+P351+P338

Discovery and Applications

Polyethylene glycol (PEG) is a synthetic polymer that was first synthesized in the early 20th century by chemists seeking to create a versatile compound with a variety of industrial and medical applications. Its discovery stemmed from the need for a polymer that was both biocompatible and soluble in water. PEG is produced by the polymerization of ethylene oxide, producing polymers with varying molecular weights and properties.

PEG is a colorless, odorless, hydrophilic polymer that is available in a wide range of molecular weights. It can exist in liquid form (low molecular weight) or solid form (high molecular weight). PEG is soluble in water and many organic solvents, and its properties can be tuned by adjusting its molecular weight and chain length. It is known for its low toxicity, making it suitable for a variety of applications in pharmaceuticals and consumer products.

PEG plays a vital role in the pharmaceutical industry. PEGylation is the process of attaching PEG chains to drugs, which enhances the solubility, stability, and bioavailability of the drug. This modification helps to prolong the circulation time of the drug in the body and reduce immunogenicity. PEGylated drugs, such as PEGylated interferon and PEGylated liposomal doxorubicin, are used to treat cancer and chronic diseases. PEG is used as a solvent and binder in oral tablets and capsules. It improves the dissolution of poorly soluble drugs and ensures sustained release of the drug.

In the medical and biotechnology fields, PEG has a variety of applications. PEG is used in medical device coatings to reduce friction and improve biocompatibility. It is also used in hydrogels for wound care and tissue engineering to provide a wet environment that is conducive to healing and cell growth. PEG is used in diagnostic assays and imaging agents to improve their performance and stability. It has helped in the development of contrast agents for MRI and other imaging techniques.

PEG is a common ingredient in a variety of consumer products. In cosmetics and personal care products, PEG is used as a humectant, emulsifier, and thickener. It is found in lotions, creams, shampoos, and toothpastes to enhance the texture and stability of the product. PEG is used as a surfactant and solubilizer in household cleaners and detergents. It helps effectively clean surfaces by improving the dispersion of the cleaning agent.

PEG is used in a variety of industrial processes. PEG is used as a base polymer in the production of various industrial polymers and resins. It helps in the development of materials with specific mechanical and chemical properties. In industrial applications, PEG is used as a lubricant in machinery and equipment. It provides effective lubrication and reduces wear.

Standard safety precautions are required for handling PEG. Although PEG is generally of low toxicity, the use of gloves and goggles is recommended to avoid direct contact. The work area should be properly ventilated. PEG should be stored in well-sealed containers in a cool, dry place to prevent contamination and degradation.

PEG has a minimal impact on the environment. PEG is biodegradable and breaks down naturally in the environment. It does not accumulate in ecosystems and is considered environmentally friendly. Proper disposal methods help mitigate any potential environmental risks associated with PEG.

References

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