Choline glycerophosphate
[CAS# 28319-77-9]

Identification

• Classification: API >> Nervous system medication >> Cholinergic
• Name: Choline glycerophosphate
• Synonyms: 2,3-Dihydroxypropyl 2-trimethylazaniumylethyl phosphate; 2-(((2,3-Dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium inner salt; L-alpha-Glycerylphosphorylcholine
• Molecular Formula: C₈H₂₀NO₆P
• Molecular Weight: 257.22
• CAS Registry Number: 28319-77-9
• EC Number: 248-962-2
• SMILES: C[N+](C)(C)CCOP(=O)([O-])OC[C@@H](CO)O

Properties

• Solubility: 10mM (water), 35 mg/mL (DMSO)

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H319-H335-H412
• Safety Statements: P261-P273-P305+P351+P338

Discovery and Applications

Choline Glycerophosphate (CGP) is a compound that has attracted much attention for its multifaceted applications in various fields. It is a derivative of glycerophosphate and choline and plays a vital role in cellular function, with a range of potential applications in health and industry.

References

2025. Safety evaluation of alpha-glycerylphosphorylcholine as a novel food. Food and Chemical Toxicology, 195.
DOI: 10.1016/j.fct.2024.115123

2024. Vertical Association Between Dietary Total Choline and L-alpha-glycerylphosphorylcholine and the Cognitive Function in Chinese Adults Aged over 55, Result from China Health and Nutrition Survey 1997-2018. Nutrients, 16(21).
DOI: 10.3390/nu16213713

2024. Efficacy and safety of choline alphoscerate for amnestic mild cognitive impairment: a randomized double-blind placebo-controlled trial. BMC Geriatrics, 24(1).
DOI: 10.1186/s12877-024-05366-7