1-Fluoro-2-(2-fluoroethoxy)ethane
[CAS# 373-21-7]

Identification

• Classification: Organic raw materials >> Organic fluorine compound
• Name: 1-Fluoro-2-(2-fluoroethoxy)ethane
• Molecular Formula: C₄H₈F₂O
• Molecular Weight: 110.10
• CAS Registry Number: 373-21-7
• SMILES: C(CF)OCCF

Properties

• Boiling Point: 127 °C (1atm)

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H320-H335
• Safety Statements: P264-P304+P340-P305+P351+P338-P337+P313

Discovery and Applications

1-Fluoro-2-(2-fluoroethoxy)ethane is a chemical compound that belongs to the class of fluorinated ethers. It is structurally characterized by the presence of a fluoro group on the first carbon and an ethoxy group attached to the second carbon, making it a fluorinated ether derivative. This compound is of interest in various fields due to its unique fluorine-containing structure.

The discovery of 1-fluoro-2-(2-fluoroethoxy)ethane is primarily rooted in its synthesis for use in chemical and pharmaceutical research. As a fluorinated ether, it is an important intermediate in the synthesis of other fluorinated organic molecules, which have a broad range of applications. The incorporation of fluorine atoms into organic molecules is a strategy that has been widely adopted in organic synthesis, as it can significantly alter the chemical, physical, and biological properties of the resulting compounds.

One of the key applications of 1-fluoro-2-(2-fluoroethoxy)ethane is in the preparation of fluorine-containing compounds used in medicinal chemistry. Fluorinated ethers, such as this compound, are often utilized in drug discovery because fluorine atoms can enhance the metabolic stability, lipophilicity, and bioavailability of pharmaceutical agents. The presence of the fluorine atoms can also impact the pharmacokinetics of the drug candidates, such as improving their resistance to enzymatic degradation.

The compound is also used in the synthesis of fluorinated polymers and materials. Due to the stability imparted by the fluorine atoms, fluorinated ethers are highly valued in the creation of durable, chemically resistant materials. These materials are used in various applications, including coatings, electronic components, and insulation, where chemical inertness and high thermal stability are important.

Additionally, 1-fluoro-2-(2-fluoroethoxy)ethane has been studied for its potential use in the production of specialty solvents. Fluorinated ethers are often preferred in solvent applications because of their low reactivity, high solubility, and ability to dissolve a wide range of compounds. In particular, the presence of fluorine can impart useful properties such as non-flammability and resistance to high temperatures, which makes such solvents ideal for use in industrial and laboratory settings.

The compound is also important in the field of chemical engineering, where fluorinated ethers are used as intermediates in the preparation of fluorine-containing chemicals. These chemicals are vital in a variety of industrial processes, including those involved in the production of refrigerants, surfactants, and polymerization agents.

In summary, 1-fluoro-2-(2-fluoroethoxy)ethane is a valuable chemical substance with diverse applications in the synthesis of fluorinated compounds, drug development, material science, and chemical manufacturing. Its fluorine-containing structure imparts a range of useful properties, making it a key intermediate for the production of specialized chemicals and materials in both industrial and research contexts.

References

2023. Fluorination in advanced battery design. Nature Reviews Materials, 9(1).
DOI: 10.1038/s41578-023-00623-4