Dutasteride Impurity 18
[CAS# 4640-41-9]

Identification

• Name: Dutasteride Impurity 18
• Synonyms: 4,5-Dichloro-3,6-dihydroxy-phthalonitrile
• Molecular Formula: C₈H₂Cl₂N₂O₂
• Molecular Weight: 229.02
• CAS Registry Number: 4640-41-9
• EC Number: 610-300-9
• SMILES: C(#N)C1=C(C(=C(C(=C1O)Cl)Cl)O)C#N

Properties

• Solubility: 1332 mg/L (25 °C water)
• Density: 1.8±0.1 g/cm³, Calc.^*
• Index of Refraction: 1.693, Calc.^*
• Melting point: 159.88 °C
• Boiling Point: 387.14 °C, 365.8±42.0 °C (760 mmHg), Calc.^*
• Flash Point: 175.0±27.9 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07;GHS09 Warning
• Risk Statements: H315-H319-H335
• Safety Statements: P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P362-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H312
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H332
Eye irritation	Eye Irrit.	2A	H319
Acute toxicity	Acute Tox.	4	H302