Resveratrol
[CAS# 501-36-0]

Identification

• Classification: API >> Antineoplastic agents >> Natural source antineoplastic agents
• Name: Resveratrol
• Synonyms: 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24
• CAS Registry Number: 501-36-0
• EC Number: 610-504-8
• SMILES: C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

Properties

• Solubility: 3 mg/100 mL (water) (Expl.)
• Density: 1.4±0.1 g/cm³, Calc.^*
• Melting point: 253-255 °C (Expl.)
• Index of Refraction: 1.763, Calc.^*
• Boiling Point: 449.1±14.0 °C (760 mmHg), Calc.^*
• Flash Point: 222.3±14.7 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS05;GHS07 Danger
• Risk Statements: H315-H318-H319-H335
• Safety Statements: P261-P264-P264+P265-P271-P280-P302+P352-P304+P340-P305+P351+P338-P305+P354+P338-P317-P319-P321-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Serious eye damage	Eye Dam.	1	H318
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Germ cell mutagenicity	Muta.	2	H341
Acute toxicity	Acute Tox.	4	H302
Skin sensitization	Skin Sens.	1	H317
Acute toxicity	Acute Tox.	4	H332
Acute toxicity	Acute Tox.	4	H312

Discovery and Applications

Resveratrol, a polyphenolic compound, was first discovered in the roots of white hellebore (Veratrum grandiflorum) in the 1940s. Its presence was later identified in other plants, including grapes, peanuts, and berries. Initially recognized for its role in the defense mechanisms of plants against pathogens and environmental stressors, resveratrol gained attention for its potential health benefits. Its discovery sparked extensive research into its biological activities and therapeutic properties.

Resveratrol is widely used as a dietary supplement due to its antioxidant properties and potential health benefits. It is believed to have anti-inflammatory, anti-cancer, and cardio-protective effects. Many people take resveratrol supplements to support heart health, reduce oxidative stress, and improve overall well-being.

Resveratrol is a common ingredient in anti-aging skincare products. Its antioxidant properties help neutralize free radicals and protect the skin from environmental damage. It promotes collagen synthesis, improves skin elasticity, and reduces the appearance of wrinkles and fine lines, making it popular in creams, serums, and moisturizers targeting skin aging.

Resveratrol has been extensively studied for its potential anti-cancer properties. Research suggests that it may inhibit the growth of cancer cells and prevent tumor formation by interfering with various cellular processes involved in cancer development. While more studies are needed to fully understand its mechanisms, resveratrol shows promise as a natural compound for cancer prevention and treatment.

Resveratrol is known for its cardioprotective effects. It helps improve cardiovascular health by reducing inflammation, lowering blood pressure, and protecting against oxidative stress. Some studies suggest that resveratrol may lower the risk of heart disease and stroke by improving blood flow and preventing the formation of blood clots.

Resveratrol has shown potential in protecting the brain and nervous system against age-related decline and neurodegenerative diseases like Alzheimer's and Parkinson's. Its antioxidant and anti-inflammatory properties may help preserve cognitive function, reduce the risk of dementia, and slow down the progression of neurodegenerative disorders.

References

2020. Microbial Natural Products: Recent Insights into Novel Applications. Bioactive Natural products in Drug Discovery.
DOI: 10.1007/978-981-15-1394-7_9

2005. Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications. Molecular Nutrition & Food Research, 49(5).
DOI: 10.1002/mnfr.200500022

2003. p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect. The Journal of biological chemistry, 278(26).
DOI: 10.1074/jbc.m300771200