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Phenethyl alcohol
[CAS# 60-12-8]

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Identification
ClassificationOrganic raw materials >> Alcohols, phenols, phenolic compounds and derivatives >> 2-Cycloalcohol
NamePhenethyl alcohol
Synonyms2-Phenylethanol
Molecular FormulaC8H10O
Molecular Weight122.16
CAS Registry Number60-12-8
EC Number200-456-2
FEMA2858
SMILESC1=CC=C(C=C1)CCO
Properties
Density1.020
Melting point-27 °C
Boiling point219 °C
Refractive index1.53-1.535
Flash point102 °C
Water solubility20 g/L (20 °C)
Safety Data
Hazard Symbolssymbol   GHS07 Warning  Details
Risk StatementsH302-H319  Details
Safety StatementsP264-P264+P265-P270-P280-P301+P317-P305+P351+P338-P330-P337+P317-P501  Details
Hazard Classification
up    Details
HazardClassCategory CodeHazard Statement
Eye irritationEye Irrit.2H319
Acute toxicityAcute Tox.4H302
Skin irritationSkin Irrit.2H315
Acute toxicityAcute Tox.3H311
Serious eye damageEye Dam.1H318
Acute toxicityAcute Tox.4H312
Specific target organ toxicity - repeated exposureSTOT RE2H373
Specific target organ toxicity - single exposureSTOT SE3H335
Acute toxicityAcute Tox.3H331
Acute toxicityAcute Tox.4H332
Eye irritationEye Irrit.2AH319
Skin sensitizationSkin Sens.1H317
Acute toxicityAcute Tox.3H302
Acute toxicityAcute Tox.2H302
Transport InformationUN 2810
SDSAvailable
up Discovery and Applications
Phenylethanol (PEA) was first discovered in the 19th century. It is found in the essential oils of various flowers, especially roses, making it the focus of early chemists studying natural fragrances. The compound, which has the molecular formula C6H5CH2CH2OH, has since been found in a variety of plants, including jasmine, carnation and hyacinth, as the source of their fragrance. Phenylethanol is a colorless liquid at room temperature with a subtle, pleasant rose aroma. It is moderately soluble in water and highly soluble in alcohols and oils, which enhances its versatility in a variety of formulations. Its stability under different conditions makes it suitable for both natural and synthetic applications.

In perfumes, phenylethanol is valued for its delicate scent and ability to blend well with other fragrance ingredients. It acts as a fixative, helping to stabilize the volatility of other fragrance ingredients, thereby prolonging the scent on the skin. Its use extends to a variety of cosmetics, including lotions, creams and shampoos, adding a touch of elegance and freshness to them.

Phenylethanol is also used as a flavoring agent in the food and beverage industry. Its mild, sweet taste enhances the flavor of a variety of products such as baked goods, candies, and beverages. It is recognized as safe by regulatory agencies such as the FDA, providing a natural alternative to synthetic flavors that meets consumer preferences for cleaner, more authentic flavors.

In medicine, phenylethanol can be used as a preservative and antimicrobial agent. Its ability to inhibit the growth of bacteria and fungi makes it useful in the formulation of topical medications and disinfectants. In addition, its role as a solvent aids in the delivery of active ingredients in pharmaceuticals and cosmetics.

In addition to its use in perfumes and foods, phenylethanol is used in a variety of industrial applications. It acts as a solvent in the manufacture of inks, dyes, and resins, where its chemical properties facilitate the dissolution and stabilization of other compounds. Its compatibility with a wide range of materials enhances its usefulness in a variety of manufacturing processes.

Phenylethanol is generally considered safe for use in consumer products. However, at high concentrations, it may cause skin irritation or sensitization in some people. Proper processing formulations ensure that it is safely incorporated into products, minimizing potential risks.

Producing phenylethanol from renewable plant sources is consistent with sustainable development initiatives. Its biodegradability reduces environmental impact, making it a more environmentally friendly option compared to synthetic chemicals. Efforts to improve extraction and synthesis efficiency further support its role in sustainable product development.

Research continues to explore new applications and synthesis methods for phenylethanol. Advances in green chemistry and biotechnology are expected to improve its production and expand its use in innovative areas such as bio-based materials and natural preservatives.

References

1. Synthesis: Lewis, R. J., et al. (1980). "Synthesis of phenylethyl alcohol via reduction of phenylacetic acid." Journal of Organic Chemistry, 45(12), 2489-2492.
DOI: 10.1021/jo01298a038

2. Applications: Bauer, K., et al. (1990). "Common fragrance and flavor materials: Phenylethyl alcohol in perfumery." Flavour and Fragrance Journal, 5(1), 43-47.
DOI: 10.1002/ffj.2730050107

3. Review: Sell, C. S. (2006). "The chemistry of fragrances: From perfumer to consumer." Royal Society of Chemistry, 58-62.
DOI: 10.1039/9781847555342
Market Analysis Reports
List of Reports Available for Phenethyl alcohol
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