Saccharin sodium dihydrate
[CAS# 6155-57-3]

Identification

• Classification: API >> Diagnostic medication >> Organ function test agent
• Name: Saccharin sodium dihydrate
• Synonyms: Sodium ortho-sulphobenzimide dihydrate
• Molecular Formula: C₇H₄NNaO₃S.2(H₂O)
• Molecular Weight: 241.19
• CAS Registry Number: 6155-57-3
• EC Number: 612-173-5
• SMILES: C1=CC=C2C(=C1)C(=O)[N-]S2(=O)=O.O.O.[Na+]

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P305+P351+P338

Discovery and Applications

Saccharin, the parent compound of saccharin sodium dihydrate, was discovered in 1879 by Constantin Fahlberg and Ira Remsen at Johns Hopkins University. Fahlberg discovered its sweetening properties accidentally while experimenting with coal tar derivatives. Saccharin sodium dihydrate is a hydrated form of saccharin sodium with enhanced stability and solubility. Its chemical formula is C7H4NO3SNa·2H2O. Saccharin sodium dihydrate is a white crystalline powder that is much sweeter than sugar - approximately 300-400 times sweeter. This high sweetness allows it to be used in small quantities, making it a popular choice for reducing calorie intake without sacrificing flavor.

Saccharin sodium dihydrate is widely used in the food and beverage industry as a non-nutritive sweetener. Its ability to maintain sweetness under a variety of conditions makes it ideal for products such as diet sodas, sugar-free desserts, and chewing gum. It is particularly valuable in baking and cooking because it is stable at high temperatures, maintaining its sweetness without breaking down.

In pharmaceuticals, saccharin sodium dihydrate is used as a sweetener in medications, particularly in chewable tablets, syrups, and tablets. Its pleasant taste improves medication palatability and patient compliance, particularly in pediatric and geriatric populations.

Saccharin sodium dihydrate is also used in personal care products such as toothpaste and mouthwash. Its intense sweetness masks the unpleasant taste of the active ingredient, resulting in a more pleasant experience for the user. Additionally, it is used in cosmetic formulations to enhance the flavor of lip balms and similar products.

Saccharin sodium dihydrate has been approved as safe for consumption by various health authorities, including the FDA. However, its use has come under scrutiny due to concerns about potential health risks in the past. Since then, numerous studies have shown that it is safe when consumed within established limits, and it currently remains a trusted sweetener in many products.

Saccharin sodium dihydrate is synthetic and not derived from natural sources, but its use reduces the need for sugar and other caloric sweeteners, indirectly supporting weight management and reducing the environmental footprint associated with sugar production. Its long shelf life and strong sweetening ability allow it to be further used in product formulations to ensure minimal waste.

Research continues to explore new formulations and applications for sodium saccharin dihydrate. It is being studied in combination with other sweeteners to improve taste and enhance sweetness synergy. Advances in food technology will expand its application range, especially in the development of innovative low-calorie and sugar-free products.

References

2024. Bioinspired slippery antifouling Co-CeO2/MoS2 coatings with excellent mechanical robustness and corrosion resistance. Journal of Solid State Electrochemistry, 28(8).
DOI: 10.1007/s10008-024-05812-x

2023. Electrochemical, spectroscopic and microscopic investigation of PEDOT coated nickel plate from aqueous micellar solutions and its anti-corrosion performances. Journal of Coatings Technology and Research, 20(2).
DOI: 10.1007/s11998-022-00724-9

2022. Congruent Electrochemical Deposition of Co-Ni-Fe Films. Russian Journal of Electrochemistry, 58(12).
DOI: 10.1134/s1023193522120072