Argireline
[CAS# 616204-22-9]

Identification

• Classification: Biochemical >> Peptide
• Name: Argireline
• Synonyms: N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-argininamide
• Molecular Formula: C₃₄H₆₀N₁₄O₁₂S
• Molecular Weight: 888.99
• Protein Sequence: EEMQRR
• CAS Registry Number: 616204-22-9
• EC Number: 801-648-4
• SMILES: CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N

Properties

• Solubility: 10 mM (water)
• Density: 1.54 g/cm³

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H335
• Safety Statements: P261-P305+P351+P338

Discovery and Applications

Argireline, also known as acetyl hexapeptide-8, was discovered by researchers studying peptides' effects on skin aging. In 1999, Dr. Martin Rodbell and his team identified its potential as a topical agent for reducing wrinkles. Unlike invasive procedures like Botox, Argireline offered a non-invasive alternative for combating signs of aging.

Argireline is a common ingredient in anti-aging creams and serums. When applied topically, it inhibits neurotransmitter release, which relaxes facial muscles, diminishing the depth of wrinkles and expression lines.

While not as potent as Botox, Argireline offers a milder alternative for individuals seeking to reduce wrinkles without injections. It provides a more natural appearance and is suitable for those with needle phobias or sensitivities.

In addition to its wrinkle-reducing properties, Argireline can improve skin hydration and firmness. By stimulating collagen production, it enhances skin elasticity, resulting in a smoother, more youthful complexion.

Argireline is not only effective for treating existing wrinkles but also for preventing their formation. Regular use of Argireline-containing products can help maintain youthful skin by minimizing the development of new wrinkles.

Argireline is often incorporated into cosmetic procedures such as micro-needling and chemical peels to enhance their anti-aging effects.

Unlike some other anti-aging compounds, Argireline is generally considered safe and non-toxic for topical use. It has undergone extensive testing for its efficacy and safety profile, making it a preferred choice for many skincare enthusiasts.

References

2023. Influence of the modification of the cosmetic peptide Argireline on the affinity toward copper(II) ions. Journal of Peptide Science, 29(7).
DOI: 10.1002/psc.3547

2021. Argireline: Needle-Free Botox as Analytical Challenge. Chemistry & Biodiversity, 18(4).
DOI: 10.1002/cbdv.202000992

2020. Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide-8. La Clinica Terapeutica, 171(6).
DOI: 10.7417/ct.2020.2270