1-Amino-4-methylpiperazine
[CAS# 6928-85-4]

Identification

• Classification: Organic raw materials >> Amino compound >> Acyclic monoamines, polyamines and their derivatives and salts
• Name: 1-Amino-4-methylpiperazine
• Synonyms: 4-Methylpiperazin-1-ylamine
• Molecular Formula: C₅H₁₃N₃
• Molecular Weight: 115.18
• CAS Registry Number: 6928-85-4
• EC Number: 230-053-7
• SMILES: CN1CCN(CC1)N

Properties

• Density: 0.957
• Boiling point: 172-175 °C
• Refractive index: 1.4835-1.4855
• Flash point: 62 °C
• Water solubility: miscible

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H312-H315-H319-H332-H335
• Safety Statements: P261-P264-P264+P265-P270-P271-P280-P301+P317-P302+P352-P304+P340-P305+P351+P338-P317-P319-P321-P330-P332+P317-P337+P317-P362+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Skin irritation	Skin Irrit.	2	H315
Specific target organ toxicity - single exposure	STOT SE	3	H335
Acute toxicity	Acute Tox.	4	H302
Acute toxicity	Acute Tox.	4	H332
Acute toxicity	Acute Tox.	4	H312
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Eye irritation	Eye Irrit.	2A	H319
Flammable liquids	Flam. Liq.	3	H226

Discovery and Applications

1-Amino-4-methylpiperazine is a compound with important applications in pharmaceuticals and organic synthesis. Also known as 4-methylpiperazin-1-amine, it was originally synthesized by modifying the piperazine molecule. Piperazine itself is a heterocyclic organic compound with a six-membered ring structure containing two nitrogen atoms at the 1 and 4 positions. 1-Amino-4-methylpiperazine is produced by introducing a methyl group (CH₃) at the 4 position of the piperazine ring and an amino group (NH₂) at the 1 position. 1-Amino-4-methylpiperazine is usually a white to off-white crystalline solid that is soluble in water and organic solvents.

1-Amino-4-methylpiperazine is a key intermediate in the synthesis of various pharmaceutical compounds: It is used in the synthesis of antiviral drugs, including antiretroviral drugs used to treat HIV/AIDS. Derivatives of 1-amino-4-methylpiperazine are used in the development of antibiotics against bacterial infections. It also plays a role in the synthesis of antidepressants and psychotropic drugs.

1-Amino-4-methylpiperazine derivatives are used as corrosion inhibitors in industrial applications, particularly in the oil and gas industry. They help protect metal surfaces from corrosion caused by acidic environments and water.

As with handling any chemical compound, proper safety precautions must be followed when working with 1-amino-4-methylpiperazine. This includes wearing appropriate personal protective equipment (PPE) and performing reactions in well-ventilated areas to minimize the risk of exposure.

Research on 1-amino-4-methylpiperazine continues to explore its potential applications in drug discovery and development. Advances in organic synthesis and medicinal chemistry are aimed at optimizing its pharmacological properties and expanding its therapeutic use in treating a variety of diseases and conditions.

References

2013. Heavy-metal extraction capability of chalcogenoic aminophosphines derived from 1-amino-4-methylpiperazine. Chemical Papers, 67(8).
DOI: 10.2478/s11696-013-0372-2

1999. Methods of gas chromatography in chemico-pharmaceutical industry. Part II. determination of the parent compound and impurities in 1-amino-4-methylpiperazine. Pharmaceutical Chemistry Journal, 33(5).
DOI: 10.1007/bf02510054

1970. Synthesis of thiourea derivatives. Pharmaceutical Chemistry Journal, 4(10).
DOI: 10.1007/bf00763243