Linalool
[CAS# 78-70-6]

Identification

• Classification: Organic raw materials >> Alcohols, phenols, phenolic compounds and derivatives >> Acyclic alcohol
• Name: Linalool
• Synonyms: 2,6-Dimethylocta-2,7-dien-6-ol; 3,7-Dimethyl-1,6-octadien-3-ol
• Molecular Formula: C₁₀H₁₈O
• Molecular Weight: 154.25
• CAS Registry Number: 78-70-6
• EC Number: 201-134-4
• FEMA: 2635
• SMILES: CC(=CCCC(C)(C=C)O)C

Properties

• Density: 0.861
• Boiling point: 199 °C
• Refractive index: 1.46-1.464
• Flash point: 75 °C
• Water solubility: 1.45 g/L (25 °C)

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H315-H317-H319
• Safety Statements: P261-P264-P264+P265-P272-P280-P302+P352-P305+P351+P338-P321-P332+P317-P333+P317-P337+P317-P362+P364-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Skin irritation	Skin Irrit.	2	H315
Eye irritation	Eye Irrit.	2	H319
Skin sensitization	Skin Sens.	1B	H317
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin sensitization	Skin Sens.	1	H317
Chronic hazardous to the aquatic environment	Aquatic Chronic	3	H412
Acute toxicity	Acute Tox.	4	H332
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Specific target organ toxicity - single exposure	STOT SE	2	H371
Skin corrosion	Skin Corr.	1B	H315
Specific target organ toxicity - single exposure	STOT SE	3	H336
Aspiration hazard	Asp. Tox.	1	H304

Discovery and Applications

Linalool was first isolated and identified from lavender oil in the 19th century by chemists who were exploring the volatile compounds responsible for its distinctive smell. It belongs to the terpene family, which are ubiquitous in nature and contribute greatly to the aroma of many plant species. In addition to lavender, linalool is also found in large quantities in herbs such as basil, rosewood and mint, as well as citrus fruits such as oranges and lemons.

Chemically, linalool is classified as a terpene alcohol with the molecular formula C10H18O. It has two enantiomers – (R)-(+)-linalool and (S)-(-)-linalool – each with its own unique aroma. The compound has a floral and citrusy scent and is a highly regarded ingredient in perfumery and aromatherapy. It is a clear, colorless liquid that is highly volatile and soluble in alcohol and oils.

Linalool is best known for its use as a fragrance compound. It is a key ingredient in many perfumes and colognes, prized for its fresh, floral notes, adding depth and complexity to aromatic compositions. In addition to fragrance, linalool is used in aromatherapy for its calming and stress-relieving properties. Inhaling or applying topically linalool-rich essential oils is thought to promote relaxation and relieve anxiety, making it an integral part of holistic wellness practices.

Linalool’s therapeutic potential extends into medicine. Studies have shown that linalool has anti-inflammatory, analgesic, and even anxiolytic effects. It has been studied for its potential in managing symptoms of anxiety disorders and chronic pain. Additionally, linalool’s antimicrobial properties can be used in topical antiseptics and as a natural preservative in cosmetics and personal care products.

In addition to its aromatic and therapeutic uses, linalool can be used in industrial and household products. It is a common ingredient in cleaners, detergents, and air fresheners, where its pleasant scent helps mask odors and create a more appealing environment. In the food industry, linalool is used as a flavoring agent in beverages, confectionery, and baked goods, helping to enhance their sensory appeal.

References

2024. Select terpenes from Cannabis sativa are antinociceptive in mouse models of post-operative pain and fibromyalgia via adenosine A2a receptors. Pharmacological reports : PR.
DOI: 10.1007/s43440-024-00687-1

2024. Aroma Alchemy: Uridine diphosphate-dependent glycosyltransferases mediated regulation of fruit aroma and flavor biosynthesis. Phytochemistry Reviews.
DOI: 10.1007/s11101-024-10049-7

2009. Rapid analysis of the essential oil components of dried Perilla frutescens (L.) by magnetic nanoparticle-assisted microwave distillation and simultaneous headspace solid-phase microextraction followed by gas chromatography-mass spectrometry. Analytical Methods, 1(1).
DOI: 10.1039/b9ay00035f