Ascorbigen
[CAS# 8075-98-7]

Identification

• Classification: Flavors and spices >> Synthetic spice >> Lactone and oxygen-containing heterocyclic compound >> Furan and pyran
• Name: Ascorbigen
• Synonyms: (3S,3aR,6aS)-3,6,6a-trihydroxy-6-(1H-indol-3-ylmethyl)-3,3a-dihydro-2H-furo[3,2-b]furan-5-one
• Molecular Formula: C₁₅H₁₅NO₆
• Molecular Weight: 305.28
• CAS Registry Number: 8075-98-7
• SMILES: C1[C@@H]([C@@H]2[C@](O1)(C(C(=O)O2)(CC3=CNC4=CC=CC=C43)O)O)O

Discovery and Applications

Ascorbic acid has gained attention in the health food industry for its potential health benefits. It is marketed as a dietary supplement and is often combined with other vitamins and antioxidants to support overall health. Research shows that ascorbic acid has antioxidant properties that help protect cells from oxidative stress and damage.

One of the most important areas of research for ascorbic acid is its potential role in cancer prevention. Some studies have shown that it can induce detoxification enzymes and inhibit the proliferation of cancer cells. Ascorbic acid's ability to regulate estrogen metabolism is particularly important in reducing the risk of hormone-dependent cancers, such as breast cancer.

Ascorbic acid is thought to enhance immune function. Its antioxidant properties help maintain the integrity of immune cells, which promotes a more robust immune response. This makes it an important ingredient in supplements designed to boost immunity, especially during times of increased susceptibility to infection.

Inflammation is a key factor in many chronic diseases, and ascorbic acid has shown promise in reducing it. It helps regulate inflammatory pathways, which offers potential benefits for conditions such as arthritis and other inflammatory diseases.

Ascorbic acid may aid in the detoxification process by enhancing the activity of enzymes involved in breaking down and eliminating toxins in the body. This detoxification effect is beneficial for overall health maintenance and protection against environmental pollutants.

In the cosmetic industry, ascorbic acid is explored for its potential benefits for skin health. Its antioxidant properties help reduce oxidative stress in the skin, potentially preventing premature aging and promoting a healthy complexion.

Ascorbic acid is generally safe, especially when consumed as part of a diet rich in cruciferous vegetables. As a dietary supplement, it should be taken at recommended doses. As with any supplement, it is recommended to consult a physician before starting to ensure appropriateness for personal health needs.

References

2014. Antioxidative properties of ascorbigen in using multiple antioxidant assays. Bioscience, Biotechnology, and Biochemistry, 78(10).
DOI: 10.1080/09168451.2014.932668

2009. Ascorbigen: chemistry, occurrence, and biologic properties. Clinics in Dermatology, 27(2).
DOI: 10.1016/j.clindermatol.2008.01.012

2008. Free Radical Scavenging and Antioxidant Activity of Ascorbigen Versus Ascorbic Acid: Studies in Vitro and in Cultured Human Keratinocytes. Journal of Agricultural and Food Chemistry, 56(22).
DOI: 10.1021/jf802403d