Dexpanthenol
[CAS# 81-13-0]

Identification

• Classification: Pharmaceutical intermediate >> Heterocyclic compound intermediate >> Pyridine compound >> Pyridine derivative
• Name: Dexpanthenol
• Synonyms: (+)-Panthenol; (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide; D-Pantothenyl alcohol; Provitamin B
• Molecular Formula: C₉H₁₉NO₄
• Molecular Weight: 205.25
• CAS Registry Number: 81-13-0
• EC Number: 201-327-3
• SMILES: CC(C)(CO)[C@H](C(=O)NCCCO)O

Properties

• Density: 1.20
• Boiling point: 118-120 °C
• Refractive index: 1.495-1.502
• alpha: 30.5 ° (c=5, H2O on anh. sub)
• Water solubility: soluble

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302-H315-H319-H332-H335
• Safety Statements: P261-P280-P305+P351+P338

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Eye irritation	Eye Irrit.	2	H319
Eye irritation	Eye Irrit.	2A	H319

Discovery and Applications

Dexpanthenol, also known as D-panthenol or provitamin B5, is an alcohol derivative of pantothenic acid that has garnered significant attention since its discovery in the 1930s. Initially identified as a component of the vitamin B complex, it is recognized for its moisturizing, healing, and anti-inflammatory properties. Dexpanthenol is widely used in pharmaceuticals, cosmetics, and personal care products, primarily due to its ability to enhance skin hydration and promote wound healing.

The discovery of dexpanthenol occurred in the early 1930s when researchers isolated pantothenic acid, a vital nutrient in the human diet. Subsequent studies highlighted the potential of its alcohol form, dexpanthenol, in biological systems, leading to its application in various health and beauty products. Its structure, which includes a hydroxyl group, enables it to penetrate the skin easily, making it an effective humectant that attracts moisture to the skin.

Dexpanthenol’s applications in dermatology are extensive. It is commonly included in topical ointments, creams, and gels intended for wound care, as it aids in tissue regeneration and reduces inflammation. Its soothing properties make it beneficial for treating burns, cuts, and other skin irritations, as it promotes faster healing and reduces the risk of infection. Dexpanthenol is also used in formulations for conditions such as eczema and dermatitis, providing relief and hydration to affected areas.

In the cosmetics industry, dexpanthenol is favored for its moisturizing effects in products like lotions, shampoos, and conditioners. Its ability to enhance skin and hair hydration improves texture and elasticity, making it a popular ingredient in formulations aimed at maintaining healthy skin and hair. Dexpanthenol is often labeled as a “skin-conditioning agent” on product ingredient lists, highlighting its role in improving product performance.

Additionally, dexpanthenol is recognized for its stability and safety profile. It is generally considered non-irritating and non-sensitizing, making it suitable for a wide range of applications, including those intended for sensitive skin. Regulatory agencies, including the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have approved its use in various concentrations, further solidifying its status as a safe and effective ingredient.

Research continues to explore the potential of dexpanthenol in other fields, including its role in enhancing the bioavailability of drugs and its application in veterinary medicine. Studies suggest that dexpanthenol may have beneficial effects in improving the quality of life for both humans and animals, further expanding its utility.

In summary, dexpanthenol is a versatile compound with significant applications in dermatology, cosmetics, and pharmaceuticals. Its discovery as a derivative of pantothenic acid has led to its widespread use as a moisturizer and healing agent, contributing to healthier skin and enhanced product performance.

References

2018. HISTOLOGICAL EVALUATION OF THERAPEUTIC EFFECTS OF DEXPANTHENOL COMPOSITION WITH CERAMIDES IN RATS WITH SKIN BURN INJURY. Georgian medical news.
URL: https://pubmed.ncbi.nlm.nih.gov/30358557

2015. The Effect of Intraurethral Dexpanthenol on Healing and Fibrosis in Rats With Experimentally Induced Urethral Trauma. Urology, 85(1).
DOI: 10.1016/j.urology.2014.09.038

2003. [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis]. Laryngo- rhino- otologie, 82(4).
DOI: 10.1055/s-2003-38941