Bis(trimethoxysilylpropyl)amine
[CAS# 82985-35-1]

Identification

• Classification: Chemical reagent >> Organic reagent >> Siloxane
• Name: Bis(trimethoxysilylpropyl)amine
• Synonyms: 3,3'-Bis(trimethoxysilyl)dipropylamine; 3-(Trimethoxysilyl)-N-(3-(trimethoxysilyl)propyl)-1-propanamine
• Molecular Formula: C₁₂H₃₁NO₆Si₂
• Molecular Weight: 341.55
• CAS Registry Number: 82985-35-1
• EC Number: 280-084-5
• SMILES: CO[Si](CCCNCCC[Si](OC)(OC)OC)(OC)OC

Properties

• Density: 1.04
• Boiling point: 152 °C (4 mmHg)
• Refractive index: 1.432
• Flash point: >110 °C

Safety Data

• Hazard Symbols: GHS05;GHS09 Danger
• Risk Statements: H318-H411
• Safety Statements: P264+P265-P273-P280-P305+P354+P338-P317-P391-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Serious eye damage	Eye Dam.	1	H318
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Skin irritation	Skin Irrit.	2	H315
Acute toxicity	Acute Tox.	4	H332
Specific target organ toxicity - single exposure	STOT SE	3	H335
Skin sensitization	Skin Sens.	1	H317
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400

• Transport Information: UN 3082

Discovery and Applications

Bis(trimethoxysilylpropyl)amine, commonly referred to as BTMSPA, is a versatile silane compound notable for its unique structure and functional properties. It was first synthesized in the late 20th century during research aimed at developing silane-based coupling agents and surface modifiers. This compound features two trimethoxysilyl groups attached to a propylamine backbone, allowing it to bridge organic and inorganic materials effectively.

One of the primary applications of BTMSPA is as a silane coupling agent in various formulations, particularly in polymer and composite industries. It serves to enhance the adhesion between inorganic fillers, such as silica or glass fibers, and organic polymers, significantly improving the mechanical properties of the resulting composites. The presence of the amine group in BTMSPA provides additional functionalities, enabling it to interact with polar surfaces and improve compatibility with various resin systems.

BTMSPA is also utilized in the field of coatings and adhesives, where its ability to promote adhesion to substrates such as glass, metals, and ceramics is invaluable. It is commonly incorporated into formulations for protective coatings, sealants, and adhesives, where it contributes to improved durability, weather resistance, and overall performance. The trimethoxysilyl groups allow for chemical bonding to surfaces, while the amine functionality enhances the reactivity of the coatings, leading to better film formation and adhesion.

In addition to its applications in composites and coatings, bis(trimethoxysilylpropyl)amine is increasingly being explored for use in various biomedical applications. Its silane groups can facilitate the functionalization of medical devices and implants, enhancing biocompatibility and reducing the risk of infection. The amine groups can also serve as sites for further chemical modification, allowing for tailored surface properties that meet specific biomedical requirements.

The use of BTMSPA is expanding into the realm of nanotechnology, where it serves as a surface modifier for nanoparticles. By coating nanoparticles with BTMSPA, researchers can improve their dispersion in organic solvents and enhance their compatibility with polymer matrices, thereby facilitating the development of advanced materials with novel properties.

Despite its many beneficial applications, the safety and environmental impact of bis(trimethoxysilylpropyl)amine are under investigation. It is essential for industries utilizing BTMSPA to adhere to regulatory guidelines and conduct thorough assessments to ensure its safe use.

In summary, bis(trimethoxysilylpropyl)amine is a multifunctional silane compound with diverse applications ranging from adhesives and coatings to biomedical and nanotechnology sectors. Its ability to enhance adhesion and compatibility between materials has made it a valuable component in advancing material science and engineering.

References

2023. Mesoporous polysilsesquioxane adsorbents with secondary amine groups for ions of metals, rare earth elements, and reactive dye removal. Applied Nanoscience, 13(6).
DOI: 10.1007/s13204-023-02919-x

2012. Highly functionalized bridged silsesquioxanes. Journal of Sol-Gel Science and Technology, 62(3).
DOI: 10.1007/s10971-012-2751-5

2012. Sol-gel derived hybrid coatings as an environment friendly surface treatment for corrosion protection of metals and their alloys. Journal of Sol-Gel Science and Technology, 64(1).
DOI: 10.1007/s10971-012-2838-z