N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alpha-asparagine
[CAS# 868844-74-0]

Identification

• Classification: Biochemical >> Peptide
• Name: N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alpha-asparagine
• Synonyms: (4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
• Molecular Formula: C₄₁H₇₀N₁₆O₁₆S
• Molecular Weight: 1075.16
• Protein Sequence: EEMQRRAD
• CAS Registry Number: 868844-74-0
• SMILES: C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)C

Properties

• Density: 1.56

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302
• Safety Statements: P280-P305+P351+P338

Discovery and Applications

N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alpha-asparagine is a complex peptide with a unique combination of amino acids, each contributing to its distinctive properties and applications. This peptide is an example of a modified peptide chain where N-acetylation has been introduced to enhance stability and functionality.

The discovery of this peptide, characterized by its specific sequence of amino acids and N-acetylation, stems from ongoing research into peptide modification and its effects on biological activity. The modification of peptides, such as N-acetylation, is a common strategy to improve the stability, solubility, and biological activity of peptides. This particular peptide sequence has been explored for its potential applications in various fields, including pharmaceuticals and biotechnology.

In the field of pharmaceuticals, the unique sequence and modification of this peptide make it a candidate for developing specialized therapeutic agents. The specific combination of amino acids, including L-alpha-glutamyl and L-methionyl residues, can impact the peptide's interaction with biological targets, potentially leading to novel drug formulations or targeted therapies. For instance, peptides with sequences like this one are often investigated for their ability to interact with specific receptors or enzymes, offering the potential for new treatments in areas such as cancer, cardiovascular diseases, or metabolic disorders.

Biotechnology applications also benefit from peptides like N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alpha-asparagine. The N-acetylation improves the peptide's stability in various conditions, making it suitable for use in protein engineering, biosensors, and as a tool in molecular biology research. In protein engineering, such peptides can be used to design and synthesize proteins with enhanced stability or specific binding properties. Biosensors utilizing these peptides can offer improved sensitivity and selectivity for detecting specific molecules or biological interactions.

Additionally, the peptide's unique sequence makes it a candidate for studying the structure-activity relationship in peptide chemistry. Researchers can use this peptide to understand how specific amino acid arrangements affect biological activity, providing insights into peptide design and optimization.

Overall, N-Acetyl-L-alpha-glutamyl-L-alpha-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alpha-asparagine represents a valuable compound in peptide chemistry with potential applications in pharmaceuticals, biotechnology, and molecular research. Its N-acetylation and specific amino acid sequence offer opportunities for novel therapeutic developments and advancements in peptide-based technologies.

References

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