mu-Conotoxin Cn IIIC
[CAS# 936616-33-0]

Identification

• Classification: API >> Antibiotics >> Peptide drug
• Name: mu-Conotoxin Cn IIIC
• Synonyms: 5-Oxo-L-prolylglycyl-L-cysteinyl-L-cysteinyl-L-asparaginylglycyl-L-prolyl-L-lysylglycyl-L-cysteinyl-L-seryl-L-seryl-L-lysyl-L-tryptophyl-L-cysteinyl-L-arginyl-L-alpha-aspartyl-L-histidyl-L-alanyl-L-arginyl-L-cysteinyl-L-cysteinamide cyclic (3→15),(4→21),(10→22)-tris(disulfide); 2-[(1R,4S,7S,10S,13S,16R,19S,22S,25S,28S,31S,34R,39R,42S,51S,54S,64R,69R)-10,54-bis(4-aminobutyl)-42-(2-amino-2-oxoethyl)-19,31-bis(3-carbamimidamidopropyl)-64-carbamoyl-4,7-bis(hydroxymethyl)-25-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-28-methyl-2,5,8,11,14,17,20,23,26,29,32,40,43,46,52,55,58,66,68-nonadecaoxo-69-[[2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]acetyl]amino]-36,37,61,62,71,72-hexathia-3,6,9,12,15,18,21,24,27,30,33,41,44,47,53,56,59,65,67-nonadecazatetracyclo[32.25.7.716,39.047,51]triheptacontan-22-yl]acetic acid
• Molecular Formula: C₉₂H₁₃₉N₃₅O₂₈S₆
• Molecular Weight: 2375.70
• Protein Sequence: XGCCNGPKGCSSKWCRDHARCC
• CAS Registry Number: 936616-33-0
• EC Number: 692-855-7
• SMILES: C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)NCC(=O)N4CCC[C@H]4C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CSSC[C@H](NC2=O)C(=O)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N3)NC(=O)CNC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC6=CN=CN6)CC(=O)O)CCCNC(=N)N)CC7=CNC8=CC=CC=C87)CCCCN)CO)CO)CCCCN)CC(=O)N)CCCNC(=N)N

Properties

• Density: 1.71±0.1 g/cm³ (20 °C 760 Torr), Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2019 ACD/Labs)

Safety Data

• Hazard Symbols: GHS06 Danger
• Risk Statements: H301+H311+H331-H301-H311-H331
• Safety Statements: P261-P262-P264-P270-P271-P280-P301+P316-P302+P352-P304+P340-P316-P321-P330-P361+P364-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	3	H311
Acute toxicity	Acute Tox.	3	H331
Acute toxicity	Acute Tox.	3	H301

Discovery and Applications

mu-Conotoxin Cn IIIC was discovered as part of ongoing research into the venom of marine cone snails, specifically Conus consors, in the early 21st century. This peptide toxin is part of a broader group of conotoxins known for their ability to selectively target ion channels and receptors in the nervous system. Researchers isolated mu-Conotoxin Cn IIIC due to its potent effects on sodium channels, making it a valuable tool for studying nerve function and potential therapeutic applications.

One of the primary applications of mu-Conotoxin Cn IIIC is in neuroscientific research. By selectively blocking specific sodium channels, it allows researchers to study the roles of these channels in nerve signal transmission and pain pathways. This specificity helps in understanding the fundamental mechanisms of nerve function and disorders.

Due to its ability to block sodium channels involved in pain transmission, mu-Conotoxin Cn IIIC has potential as a novel pain management therapy. Its specificity for certain sodium channels could provide pain relief without the side effects associated with traditional analgesics like opioids.

Sodium channels play a crucial role in cardiac function. mu-Conotoxin Cn IIIC can be used to study these channels' roles in heart muscle contraction and arrhythmias. By providing insights into the molecular mechanisms of heart function and dysfunction, it can contribute to the development of new treatments for heart disease.

The high specificity and potency of mu-Conotoxin Cn IIIC make it a valuable tool in biotechnology. It can be used in the development of diagnostic assays for sodium channel function and in the screening of new drugs targeting these channels.

Ongoing research aims to modify and optimize mu-Conotoxin Cn IIIC for therapeutic use. Its potential in treating neurological disorders, such as epilepsy and multiple sclerosis, is being explored.

References

none