MOG (35-55)

CAS 149635-73-4

MOG (35–55) names a twenty-one-residue fragment, counted from positions 35 through 55 of a protein associated with myelin. The CAS entry identifies the mouse and rat peptide, not the entire glycoprotein. Its scientific value lies in a question about recognition: does a fragment examined directly show the same immune response as a fragment generated from an intact protein? Cells process proteins and present selected pieces, so a sequence can be present in a protein without being displayed in a particular setting. Studies of this region distinguished naturally processed and cryptic sites of recognition. Those results help explain how immune responses depend on the form and presentation of a protein. They do not identify the cause of disease in an individual person.