Global Chemical Database

N-(Trifluoroacetyl)glycine

CAS 383-70-0

N-(Trifluoroacetyl)glycine
Sometimes the most useful thing a chemist can tell part of a molecule is:
—Not yet.— Glycine contains two reactive groups: an amine and a carboxylic acid. Suppose a chemist wants to use the acid but needs the amine to stay out of the way. One solution is protection.

In N-(trifluoroacetyl)glycine, the amino group is temporarily converted into a trifluoroacetamide. The CF3CO- group strongly changes the nitrogen's electronic behavior. Instead of acting like a reactive free amine, the nitrogen becomes much quieter. Now chemistry can happen elsewhere.
Published: 2026-08-16
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