Sodium gluconate
[CAS# 527-07-1]

Identification

• Classification: Organic raw materials >> Organometallic salt
• Name: Sodium gluconate
• Synonyms: D-Gluconic acid, monosodium salt; Gluconic acid sodium salt
• Molecular Formula: C₆H₁₁NaO₇
• Molecular Weight: 218.14
• CAS Registry Number: 527-07-1
• EC Number: 208-407-7
• SMILES: C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Na+]

Properties

• Solubility: 10 mM (H2O)
• Melting point: 206-209 ºC
• alpha: 20 º

Safety Data

• Hazard Symbols: GHS07 Warning
• Hazard Statements: H302-H315-H319-H335
• Precautionary Statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Discovory and Applicatios

Sodium gluconate is the sodium salt of gluconic acid, first synthesized and identified in the early 20th century. Its discovery stemmed from the pursuit of new chemical compounds with unique properties, particularly in the field of organic chemistry. Sodium gluconate was initially recognized for its chelating ability (forming stable complexes with metal ions), and then quickly attracted attention for its potential industrial applications.

The versatility of sodium gluconate soon led to practical applications in various industries. Its role as a chelating agent plays a key role in industrial cleaning formulations, where it effectively binds to metal ions in water, preventing scaling and improving the efficiency of detergents. This property also extends its use to concrete admixtures, where it acts as a water reducer and retarder, improving the workability and durability of concrete mixes.

In the construction sector, the role of sodium gluconate is not limited to concrete admixtures. It can act as a corrosion inhibitor on metal surfaces, protecting structural integrity in harsh environments. In addition, its ability to control the hydration rate of cement has helped in the development of high-performance concrete, providing a sustainable solution for infrastructure projects around the world.

In addition to the construction industry, sodium gluconate can also be used in the food and pharmaceutical industries. As a food additive, it acts as a chelating agent and stabilizer, regulating acidity and extending the shelf life of various products. In pharmaceutical formulations, it improves drug solubility and bioavailability, facilitating effective drug delivery systems.

With the growing emphasis on sustainability, the biodegradability and low toxicity of sodium gluconate position it favorably in green chemistry initiatives. Its role as an environmentally friendly alternative to traditional chemical additives highlights its importance in promoting environmentally friendly practices across industries.

Ongoing research continues to explore new applications for sodium gluconate and improve its manufacturing processes. Advances in biotechnology and chemical engineering are expected to further expand its use, particularly in areas such as nanotechnology and biomedicine. The pursuit of innovative uses highlights the potential of sodium gluconate to drive future technological advancements.

References

1986. Immunorestoration in cancer patients by sodium gluconate. Anticancer Research, 6(3).
DOI: 10.1016/0277-5379(86)90198-0

2024. Effect of sodium gluconate and rice husk ash on the properties of 3D printed recycled coarse aggregate concrete. Journal of Building Engineering, 96.
DOI: 10.1016/j.jobe.2024.110618

2024. Effects of sodium gluconate on the rheological and gel properties of pea protein isolate. Food Hydrocolloids, 155.
DOI: 10.1016/j.foodhyd.2024.110234