Kathon 886
[CAS# 55965-84-9]

Identification

• Classification: Organic raw materials >> Ketone compound
• Name: Kathon 886
• Synonyms: Kathon WT; Kathon biocide; 5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone
• Molecular Formula: C₄H₅NOS^.C₄H₄ClNOS
• CAS Registry Number: 55965-84-9 (96118-96-6)
• EC Number: 911-418-6
• SMILES: CN1C(=O)C=CS1.CN1C(=O)C=C(S1)Cl

Properties

• Density: 1.015 g/mL
• Melting point: 0 ºC
• Boiling point: 100 ºC

Safety Data

• Hazard Symbols: GHS05;GHS06;GHS07;GHS09 Danger
• Hazard Statements: H301-H310-H311-H314-H317-H318-H330-H331-H400-H410
• Precautionary Statements: P260-P261-P262-P264-P264+P265-P270-P271-P272-P273-P280-P284-P301+P316-P301+P330+P331-P302+P352-P302+P361+P354-P304+P340-P305+P354+P338-P316-P317-P320-P321-P330-P333+P317-P361+P364-P362+P364-P363-P391-P403+P233-P405-P501

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute hazardous to the aquatic environment	Aquatic Acute	1	H400
Chronic hazardous to the aquatic environment	Aquatic Chronic	1	H410
Acute toxicity	Acute Tox.	3	H301
Skin sensitization	Skin Sens.	1	H317
Acute toxicity	Acute Tox.	3	H331
Acute toxicity	Acute Tox.	3	H311
Skin corrosion	Skin Corr.	1B	H314
Serious eye damage	Eye Dam.	1	H318
Acute toxicity	Acute Tox.	2	H310
Acute toxicity	Acute Tox.	2	H330
Skin corrosion	Skin Corr.	1C	H314
Skin sensitization	Skin Sens.	1A	H317
Skin corrosion	Skin Corr.	1	H314

Discovory and Applicatios

Kathon 886 is a widely used biocide and preservative that plays a crucial role in preventing microbial growth in various industrial applications. This compound is a broad-spectrum antimicrobial agent, primarily utilized in the preservation of products and materials to enhance their longevity and stability.

The discovery of Kathon 886 dates back to the early 1970s when researchers sought effective solutions to combat microbial contamination in industrial settings. The compound is a mixture of two active ingredients: 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one. These components are known for their ability to inhibit a wide range of bacteria, fungi, and yeasts, making Kathon 886 a versatile and effective preservative.

Kathon 886 is predominantly used in water-based formulations, including paints, coatings, adhesives, and personal care products. In the paint and coating industry, it helps prevent the growth of microorganisms that can spoil the product and degrade its quality over time. Its inclusion in these products ensures that they maintain their efficacy and appearance throughout their intended shelf life.

In the personal care industry, Kathon 886 is employed in a variety of products such as shampoos, conditioners, and lotions. Its antimicrobial properties help extend the shelf life of these products by preventing the growth of bacteria and fungi that could otherwise lead to contamination and spoilage. This contributes to the safety and effectiveness of personal care products, ensuring that they remain hygienic for the duration of their use.

The use of Kathon 886 is also significant in the manufacturing of adhesives and sealants. These products are often exposed to moisture, which can create an environment conducive to microbial growth. By incorporating Kathon 886, manufacturers can enhance the durability and performance of adhesives and sealants, ensuring that they remain effective in various applications.

Despite its effectiveness, the use of Kathon 886 has raised some concerns regarding its potential for causing allergic reactions in sensitive individuals. As a result, regulatory agencies have established guidelines to limit its concentration in consumer products to mitigate any potential health risks. Manufacturers must adhere to these guidelines to ensure the safe use of Kathon 886 in their products.

In summary, Kathon 886 is a valuable biocide with widespread applications in industrial and consumer products. Its ability to inhibit microbial growth makes it an essential component in preserving the quality and safety of a range of products, from paints and coatings to personal care items and adhesives. While its benefits are well-established, careful management of its concentration in products helps address health concerns and ensures its safe use.

References

2021. Effects of Kathon, a Chemical Used Widely as a Microbicide, on the Survival of Two Species of Mosquitoes. Molecules, 26(14).
DOI: 10.3390/molecules26144177

2020. A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn2+ and generating reactive oxygen species. Archives of Toxicology, 94(12).
DOI: 10.1007/s00204-020-02930-z

2023. Patch tests and hand eczema: retrospective study in 173 patients and literature review. Anais Brasileiros de Dermatologia, 98(3).
DOI: 10.1016/j.abd.2022.02.007