Pyrimethamine
[CAS# 58-14-0]

Identification

• Classification: API >> Antiparasitic drug >> Antimalarial
• Name: Pyrimethamine
• Synonyms: 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
• Molecular Formula: C₁₂H₁₃ClN₄
• Molecular Weight: 248.71
• CAS Registry Number: 58-14-0
• EC Number: 200-364-2

Properties

• Melting point: 233-234 ºC
• Water solubility: <0.01 g/100 mL at 21 ºC

Safety Data

• Hazard Symbols: Xn
• Risk Codes: R22

Hazard Classification

Hazard	Class	Category Code	Hazard Statement
Acute toxicity	Acute Tox.	4	H302
Chronic hazardous to the aquatic environment	Aquatic Chronic	2	H411
Reproductive toxicity	Repr.	2	H361
Eye irritation	Eye Irrit.	2	H319
Specific target organ toxicity - repeated exposure	STOT RE	2	H373
Specific target organ toxicity - single exposure	STOT SE	2	H371
Acute hazardous to the aquatic environment	Aquatic Acute	2	H401
Acute toxicity	Acute Tox.	3	H301
Germ cell mutagenicity	Muta.	2	H341
Specific target organ toxicity - single exposure	STOT SE	3	H371
Skin irritation	Skin Irrit.	2	H315