Collagens polypeptide
[CAS# 9007-34-5]

Identification

• Classification: API >> Special medicine >> Dermatology medication
• Name: Collagens polypeptide
• Synonyms: L-Lysyl-L-prolylglycyl-L-alpha-glutamyl-L-prolylglycyl-L-prolyl-L-lysine
• Molecular Formula: C₂₅H₄₈N₄O₅
• Molecular Weight: 484.67
• CAS Registry Number: 9007-34-5
• EC Number: 232-697-4
• SMILES: CCCCNC(=O)C(C)CC(C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C)O

Properties

• Solubility: 0.5-2.0 mg/mL (acetic acid dissolve for several hours at 2-8 °C)
• Density: 1.3±0.1 g/cm³, Calc.^*
• Melting point: 37 °C
• Index of Refraction: 1.582, Calc.^*
• Boiling Point: 1275.9±65.0 °C (760 mmHg), Calc.^*
• Flash Point: 725.4±34.3 °C, Calc.^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Discovery and Applications

Collagen peptides are essential components of various biological processes and have attracted great interest due to their wide range of applications in medicine, cosmetics, and biotechnology. The discovery of collagen dates back to the early 20th century, when researchers began to understand the composition and structure of connective tissue. Collagen is the major structural protein in the extracellular matrix of animal tissues and is composed of long polypeptide chains. These chains are rich in glycine, proline, and hydroxyproline, which make up collagen's unique triple helical structure. The ability to isolate and study collagen peptides is essential to understanding their role in various physiological processes.

Collagen peptides are characterized by their unique triple helical conformation, which provides structural integrity and strength to tissues. They are highly flexible, insoluble in water, and have significant tensile strength. The high glycine content allows the helices to be tightly packed, while proline and hydroxyproline stabilize the structure through hydrogen bonding. These properties make collagen peptides suitable for a variety of applications that require durability and biocompatibility.

Collagen peptides are widely used in medical applications due to their biocompatibility and ability to promote tissue regeneration. They are used in wound healing products such as dressings and grafts to support the natural healing process. Collagen-based scaffolds are also used in tissue engineering to provide a framework for new tissue growth, particularly in cartilage and bone repair. In addition, collagen peptides are used in dermal fillers and skin regeneration treatments for cosmetic surgery.

In the cosmetics industry, collagen peptides are popular for their anti-aging properties. They are added to creams, lotions, and serums to enhance skin hydration, elasticity, and firmness. Peptides penetrate the skin and stimulate the production of new collagen, reducing the appearance of wrinkles and fine lines. Hydrolyzed collagen is composed of smaller peptides and is particularly effective in skin care formulations due to its ability to penetrate into the deeper layers of the skin.

Collagen peptides are also used in nutritional supplements to improve joint health, skin elasticity, and overall well-being. These supplements typically contain hydrolyzed collagen, which is more easily absorbed by the body. Regular intake of collagen supplements can support the maintenance of healthy joints, skin, hair, and nails.

In biotechnology, collagen peptides are used as biomaterials for drug delivery systems and substrates for cell culture. Their biocompatibility and ability to interact with cells make them ideal for creating controlled-release drug delivery platforms. Additionally, collagen-coated surfaces are often used in laboratory settings to support the growth and differentiation of various cell types.

The food industry uses collagen peptides to produce gelatin, which is a partially hydrolyzed form of collagen. Gelatin is widely used as a gelling agent in foods such as jellies, marshmallows, and soft candies. It can also be used as a stabilizer and thickener for various foods, enhancing texture and mouthfeel.

The future of collagen peptides lies in the development of advanced biomaterials and regenerative medicine. Ongoing research is aimed at improving the functionality and application of collagen-based products, including the creation of synthetic collagen with enhanced properties. Innovations in collagen extraction and processing technologies are expected to expand its application in various industries, providing new opportunities in medical, skin care, and biotechnology.

References

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